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R Rizzuto

Explore the profile of R Rizzuto including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 109
Citations 8055
Followers 0
Related Specialties
Biochemistry
Cell Biology
Molecular Biology
Top 10 Co-Authors
T Pozzan
M Brini
P Pinton
M Murgia
E A Schon
C Bastianutto
G A Rutter
H Nakase
M Zeviani
S DiMauro
Published In
Cell Death Differ
J Biol Chem
Cell Calcium
EMBO J
J Cell Biol
Affiliations
Soon will be listed here.
Recent Articles
1.
Reduced mitochondrial Ca(2+) transients stimulate autophagy in human fibroblasts carrying the 13514A>G mutation of the ND5 subunit of NADH dehydrogenase
Granatiero V, Giorgio V, Cali T, Patron M, Brini M, Bernardi P, et al.
Cell Death Differ . 2015 Jul; 23(2):231-41. PMID: 26206091
Mitochondrial disorders are a group of pathologies characterized by impairment of mitochondrial function mainly due to defects of the respiratory chain and consequent organellar energetics. This affects organs and tissues...
2.
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
Galluzzi L, Bravo-San Pedro J, Vitale I, Aaronson S, Abrams J, Adam D, et al.
Cell Death Differ . 2014 Sep; 22(1):58-73. PMID: 25236395
Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally...
3.
Signalling pathways regulating muscle mass in ageing skeletal muscle: the role of the IGF1-Akt-mTOR-FoxO pathway
Sandri M, Barberi L, Bijlsma A, Blaauw B, Dyar K, Milan G, et al.
Biogerontology . 2013 May; 14(3):303-23. PMID: 23686362
During ageing skeletal muscles undergo a process of structural and functional remodelling that leads to sarcopenia, a syndrome characterized by loss of muscle mass and force and a major cause...
4.
PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress
Verfaillie T, Rubio N, Garg A, Bultynck G, Rizzuto R, Decuypere J, et al.
Cell Death Differ . 2012 Jun; 19(11):1880-91. PMID: 22705852
Endoplasmic reticulum stress is emerging as an important modulator of different pathologies and as a mechanism contributing to cancer cell death in response to therapeutic agents. In several instances, oxidative...
5.
Intracellular targeting of the photoprotein aequorin: A new approach for measuring, in living cells, Ca(2+) concentrations in defined cellular compartments
Rizzuto R, Brini M, Pozzan T
Cytotechnology . 2012 Feb; 11(Suppl 1):S44-6. PMID: 22358706
We here present a novel method, based on the targeting of the photoprotein aequorin, for measuring the concentration of Ca(2+) ions in defined cellular compartments of intact cells. In this...
6.
TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis
Rojas-Rivera D, Armisen R, Colombo A, Martinez G, Eguiguren A, Diaz A, et al.
Cell Death Differ . 2012 Jan; 19(6):1013-26. PMID: 22240901
Transmembrane BAX inhibitor motif-containing (TMBIM)-6, also known as BAX-inhibitor 1 (BI-1), is an anti-apoptotic protein that belongs to a putative family of highly conserved and poorly characterized genes. Here we...
7.
VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria
De Stefani D, Bononi A, Romagnoli A, Messina A, De Pinto V, Pinton P, et al.
Cell Death Differ . 2011 Jul; 19(2):267-73. PMID: 21720385
Voltage-dependent anion channels (VDACs) are expressed in three isoforms, with common channeling properties and different roles in cell survival. We show that VDAC1 silencing potentiates apoptotic challenges, whereas VDAC2 has...
8.
Calcium signalling-dependent mitochondrial dysfunction and bioenergetics regulation in respiratory chain Complex II deficiency
Mbaya E, Oules B, Caspersen C, Tacine R, Massinet H, Pennuto M, et al.
Cell Death Differ . 2010 May; 17(12):1855-66. PMID: 20489732
Despite advanced knowledge on the genetic basis of oxidative phosphorylation-related diseases, the molecular and/or cellular determinants for tissue-specific dysfunction are not completely understood. Here, we report the cellular events associated...
9.
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
Galluzzi L, Aaronson S, Abrams J, Alnemri E, Andrews D, Baehrecke E, et al.
Cell Death Differ . 2009 Apr; 16(8):1093-107. PMID: 19373242
Cell death is essential for a plethora of physiological processes, and its deregulation characterizes numerous human diseases. Thus, the in-depth investigation of cell death and its mechanisms constitutes a formidable...
10.
Age-related changes in levels of p66Shc and serine 36-phosphorylated p66Shc in organs and mouse tissues
Lebiedzinska M, Duszynski J, Rizzuto R, Pinton P, Wieckowski M
Arch Biochem Biophys . 2009 Mar; 486(1):73-80. PMID: 19327338
Mammalian life span can be controlled by p66Shc protein through regulation of cellular response to oxidative stress. We investigated age-related changes in the amount of p66Shc and its Ser36-phosphorylated form...