R M Wadkins
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Explore the profile of R M Wadkins including associated specialties, affiliations and a list of published articles.
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22
Citations
218
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Recent Articles
1.
Hatfield M, Tsurkan L, Hyatt J, Yu X, Edwards C, Hicks L, et al.
Br J Pharmacol
. 2010 Jul;
160(8):1916-28.
PMID: 20649590
Background And Purpose: Carboxylesterases (CEs) metabolize a wide range of xenobiotic substrates including heroin, cocaine, meperidine and the anticancer agent CPT-11. In this study, we have purified to homogeneity human...
2.
Wadkins R, Morton C, Weeks J, Oliver L, Wierdl M, Danks M, et al.
Mol Pharmacol
. 2001 Jul;
60(2):355-62.
PMID: 11455023
7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin [CPT-11 (irinotecan)] is a water-soluble camptothecin-derived prodrug that is activated by esterases to yield the potent topoisomerase I poison SN-38. We identified a rabbit liver carboxylesterase (CE) that was...
3.
The role of the loop in binding of an actinomycin D analog to hairpins formed by single-stranded DNA
Wadkins R, Tung C, Vallone P, Benight A
Arch Biochem Biophys
. 2001 Jan;
384(1):199-203.
PMID: 11147831
Our recent work has indicated that the potent antibiotic and antitumor agent actinomycin D has the ability to selectively bind and stabilize single-stranded DNA that is capable of adopting a...
4.
Vladu B, Woynarowski J, Manikumar G, Wani M, Wall M, Von Hoff D, et al.
Mol Pharmacol
. 2000 Jan;
57(2):243-51.
PMID: 10648633
7-Alkyl, 7-alkyl-10-hydroxy, 7-alkyl-10-methoxy, and 7-alkyl-10, 11-methylenedioxy analogs of camptothecin have been synthesized and evaluated for their ability to trap human DNA topoisomerase I in cleavable complexes. The 7-alkyl chain lengths...
5.
Wadkins R
Curr Med Chem
. 2000 Jan;
7(1):1-15.
PMID: 10637354
DNA secondary structures containing regions of single-stranded DNA have now been identified in the genomic DNA of a number of prokaryotic and eukaryotic species, including humans. Many of these secondary...
6.
Wadkins R, Potter P, Vladu B, Marty J, Mangold G, Weitman S, et al.
Cancer Res
. 1999 Jul;
59(14):3424-8.
PMID: 10416605
Water-soluble 20(S)-glycinate esters of two highly potent 10,11-methylenedioxy analogues of camptothecin (CPT) have been synthesized and evaluated for their ability to eradicate human breast cancer tumor xenografts. The glycinate ester...
7.
Morton C, Wadkins R, Danks M, Potter P
Cancer Res
. 1999 Apr;
59(7):1458-63.
PMID: 10197614
Patients treated with high doses of CPT-11 rapidly develop a cholinergic syndrome that can be alleviated by atropine. Although CPT-11 was not a substrate for acetylcholinesterase (AcChE), in vitro assays...
8.
Wadkins R, Vladu B, Tung C
Biochemistry
. 1998 Aug;
37(34):11915-23.
PMID: 9718315
We have examined the role of DNA composition in the binding of actinomycin D to single-stranded DNA. By using the fluorescent analogue 7-aminoactinomycin D, we were able to monitor binding...
9.
Wadkins R, Golden J, Pritsiolas L, Ligler F
Biosens Bioelectron
. 1998 Jun;
13(3-4):407-15.
PMID: 9642774
A planar array immunosensor, equipped with a charge-coupled device (CCD) as a detector, was used to simultaneously detect 3 toxic analytes. Wells approximately 2 mm in diameter were formed on...
10.
Wadkins R, Danks M, Horowitz L, Baker S
Exp Cell Res
. 1998 Jun;
241(2):332-9.
PMID: 9637775
Topographical image measures have been used to characterize the subnuclear distribution of DNA topoisomerase I in human tumor cell lines. This topographical analysis allowed a mathematical description of staining patterns...