P M Potter
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Explore the profile of P M Potter including associated specialties, affiliations and a list of published articles.
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42
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637
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Recent Articles
1.
Hatfield M, Tsurkan L, Hyatt J, Yu X, Edwards C, Hicks L, et al.
Br J Pharmacol
. 2010 Jul;
160(8):1916-28.
PMID: 20649590
Background And Purpose: Carboxylesterases (CEs) metabolize a wide range of xenobiotic substrates including heroin, cocaine, meperidine and the anticancer agent CPT-11. In this study, we have purified to homogeneity human...
2.
Wierdl M, Tsurkan L, Hyatt J, Edwards C, Hatfield M, Morton C, et al.
Cancer Gene Ther
. 2008 Jan;
15(3):183-92.
PMID: 18188187
CPT-11 is a potent antitumor agent that is activated by carboxylesterases (CE) and intracellular expression of CEs that can activate the drug results in increased cytotoxicity to the drug. As...
3.
Redinbo M, Bencharit S, Potter P
Biochem Soc Trans
. 2003 May;
31(Pt 3):620-4.
PMID: 12773168
Human carboxylesterase 1 (hCE1) is a serine esterase involved in both drug metabolism and activation, as well as other biological processes. hCE1 catalyses the hydrolysis of heroin and cocaine, and...
4.
Wadkins R, Morton C, Weeks J, Oliver L, Wierdl M, Danks M, et al.
Mol Pharmacol
. 2001 Jul;
60(2):355-62.
PMID: 11455023
7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin [CPT-11 (irinotecan)] is a water-soluble camptothecin-derived prodrug that is activated by esterases to yield the potent topoisomerase I poison SN-38. We identified a rabbit liver carboxylesterase (CE) that was...
5.
Meck M, Wierdl M, Wagner L, Burger R, Guichard S, Krull E, et al.
Cancer Res
. 2001 Jun;
61(13):5083-9.
PMID: 11431345
Tumor cells that contaminate hematopoietic cell preparations contribute to the relapse of neuroblastoma patients who receive autologous stem cell rescue as a component of therapy. Therefore, effective purging methods are...
6.
Wierdl M, Morton C, Weeks J, Danks M, Harris L, Potter P
Cancer Res
. 2001 Jun;
61(13):5078-82.
PMID: 11431344
Irinotecan, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) is activated by carboxylesterases (CE) to yield the potent topoisomerase I inhibitor, SN-38. We have demonstrated previously that a rabbit liver CE is approximately 100-1000-fold more efficient...
7.
Iyengar R, Pawlik C, Krull E, Phelps D, Burger R, Harris L, et al.
Cancer Res
. 2001 Apr;
61(7):3045-52.
PMID: 11306486
One of the advantages of viral-directed enzyme prodrug therapy (VDEPT) is its potential for tumor-specific cytotoxicity. However, the viruses used to deliver cDNAs encoding prodrug-activating enzymes transduce normal cells as...
8.
Morton C, Potter P
Mol Biotechnol
. 2001 Mar;
16(3):193-202.
PMID: 11252804
Expression of a rabbit liver carboxylesterase has been achieved in several different model systems including Escherichia coli, Pichia pastoris, Saccharomyces cerevisiae, Spodoptera frugiperda, and COS7 cells. Although, recombinant protein was...
9.
Khanna R, Morton C, Danks M, Potter P
Cancer Res
. 2000 Sep;
60(17):4725-8.
PMID: 10987276
Irinotecan [7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11)] is metabolized by esterases to yield the potent topoisomerase I poison 7-ethyl-10-hydroxycamptothecin. One of the major side effects observed with CPT-11 is gastrointestinal toxicity, and we supposed...
10.
Potter P, McKenzie P, Hussain N, Noonberg S, Morton C, Harris L
Mol Biotechnol
. 2000 Aug;
15(2):105-14.
PMID: 10949823
A series of plasmid vectors have been generated to allow the rapid construction of adenoviral vectors designed to express small RNA sequences. A truncated human U6 gene containing convenient restriction...