R Ledger
Overview
Explore the profile of R Ledger including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
27
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Recent Articles
1.
Wen J, McLeod B, Tucker I, Davies N, Ledger R, Butt A
J Pharm Sci
. 2007 May;
96(9):2262-73.
PMID: 17506515
We have identified differences in transport properties of intestinal epithelia in the marsupial brushtail possum, compared to eutherian mammals. To determine whether differences in its permeability to hydrophilic compounds also...
2.
Ledger R, Tucker I, Walker G
J Control Release
. 2002 Dec;
85(1-3):91-103.
PMID: 12480315
Oral delivery of peptide and protein drugs has potential advantages for the aquaculture industry. The bioavailability of proteins and peptides from the intestinal tract is very low. This can be...
3.
Wen J, Ledger R, Butt A, McLeod B, Davies N, Tucker I
J Pharm Pharmacol
. 2002 Oct;
54(10):1365-72.
PMID: 12396298
The proteolytic activity of luminal extracts from five regions (duodenum, jejunum, ileum, caecum and colon) of the brushtail possum intestine towards bovine serum albumin (BSA) and human luteinizing hormone releasing...
4.
Wen J, Ledger R, McLeod B, Davies N, Butt A, Tucker I
Life Sci
. 2002 Oct;
71(25):3019-30.
PMID: 12384185
The peptidolytic activity of fresh and frozen mucosal homogenates from five regions (duodenum, jejunum, ileum, caecum and colon) of possum intestine from Trichosurus vulpecula towards human Luteinizing Hormone Releasing Hormone...
5.
Wen J, Ledger R, McLeod B, Davies N, Butt A, Tucker I
J Comp Physiol B
. 2002 Oct;
172(7):553-9.
PMID: 12355223
A protein (bovine serum albumin: BSA) and a peptide (luteinizing hormone releasing hormone: LHRH) were used to evaluate proteolytic activity in the intestine of common brushtail possums (Marsupiala, Trichosurus vulpecula)....
6.
Fawcett J, Kennedy J, Kumar A, Ledger R, Kumara G, Patel M, et al.
J Pharm Pharm Sci
. 2002 Sep;
5(2):199-204.
PMID: 12207874
Purpose: To compare the efficacy and pharmacokinetics of racemic bupivacaine (rac-bupivacaine) with S-bupivacaine as primary local anesthetic agent in bilateral impacted third molar extractions. Method: A randomised, double blind, two...
7.
Ball P, Bethune K, Fox J, Ledger R, Barnett M
Nutrition
. 2001 Dec;
17(11-12):926-9.
PMID: 11744342
Objectives: In consideration of a US Federal Drug Administration recommendation that all parenteral nutrition admixtures should be administered through an in-line filtration device, this observational study examined the number, size...
8.
Mills D, Ledger R
Prog Neuropsychopharmacol Biol Psychiatry
. 2001 Oct;
25(8):1597-613.
PMID: 11642657
1. Twenty two healthy, non-problem dogs were assessed for their acquisition of three different learning tasks on consecutive days and on the extinction of the response in the third. In...
9.
Walker G, Ledger R, Tucker I
Int J Pharm
. 2001 Mar;
216(1-2):77-82.
PMID: 11274809
LHRH and its analogues have low oral bioavailability; this is in part due to their degradation by peptidases present in the intestinal lumen. To determine the appropriate inhibitors to co-administer...
10.
Walker G, Ledger R, Tucker I
Pharm Res
. 1999 Aug;
16(7):1074-80.
PMID: 10450933
Purpose: To determine the mechanism by which Carbomer inhibits the enzymatic activity of trypsin in hydrolysis of N-alpha-benzoyl-L-arginine ethyl ester (BAEE) and luteinizing hormone-releasing hormone (LHRH). Methods: Inhibition of enzymatic...