R L Shepard
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Explore the profile of R L Shepard including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
198
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Recent Articles
1.
Dantzig A, LaLonde R, Ramdayal F, Shepard R, Yanai K, Zhang M
J Med Chem
. 2001 Feb;
44(2):180-5.
PMID: 11170627
Derivatives of alpha-conidendrin, podophyllotoxin, and sikkimotoxin were prepared to evaluate the cytotoxic contributions of C-4 configuration and pendant and fused arene substitutions. Dimethyl-alpha-conidendryl alcohol (5), 9-deoxypodophyllol (6), and 9-deoxysikkimol (17)...
2.
Scism J, Laska D, Horn J, Gimple J, Pratt S, Shepard R, et al.
In Vitro Cell Dev Biol Anim
. 1999 Dec;
35(10):580-92.
PMID: 10614867
Cocultures of human umbilical vein endothelial cells (ECV304) and rat glioma cells (C6) from two commercial sources, American Type Culture Collection and European Collection of Animal Cell Cultures, were evaluated...
3.
Norman B, Dantzig A, Kroin J, Law K, Tabas L, Shepard R, et al.
Bioorg Med Chem Lett
. 1999 Dec;
9(23):3381-6.
PMID: 10612603
The benzothiophene LY329146 reverses the drug resistance phenotype in multidrug resistance protein (MRP1)-overexpressing cells when dosed in combination with MRP1-associated oncolytics doxorubicin and vincristine. Additionally, LY329146 inhibited MRP1-mediated uptake of...
4.
Dantzig A, Shepard R, Law K, Tabas L, Pratt S, Gillespie J, et al.
J Pharmacol Exp Ther
. 1999 Jul;
290(2):854-62.
PMID: 10411602
Overexpression of ATP-dependent drug efflux pumps, P-glycoprotein (Pgp) or multidrug resistance-associated protein (MRP), confers multidrug resistance to tumor cells. Modulators of multidrug resistance block the action of these pumps, thereby...
5.
Effect of modulators on the ATPase activity and vanadate nucleotide trapping of human P-glycoprotein
Shepard R, Winter M, Hsaio S, Pearce H, Beck W, Dantzig A
Biochem Pharmacol
. 1998 Sep;
56(6):719-27.
PMID: 9751076
P-Glycoprotein (Pgp) is responsible for the energy-dependent efflux of many natural product oncolytics. Overexpression of Pgp may result in multidrug resistance (MDR). Modulators can block Pgp efflux and sensitize multidrug...
6.
Starling J, Shepard R, Cao J, Law K, Norman B, Kroin J, et al.
Adv Enzyme Regul
. 1997 Jan;
37:335-47.
PMID: 9381979
The above data indicate that LY335979 displays the following characteristics of an 'ideal modulator' of Pgp-mediated multidrug resistance: high affinity binding to Pgp, high potency for in vitro reversal of...
7.
Dantzig A, Shepard R, Cao J, Law K, Ehlhardt W, Baughman T, et al.
Cancer Res
. 1996 Sep;
56(18):4171-9.
PMID: 8797588
Overexpression of P-glycoprotein (Pgp) by tumors results in multidrug resistance (MDR) to structurally unrelated oncolytics. MDR cells may be sensitized to these oncolytics when treated with a Pgp modulator. The...
8.
Dantzig A, Hoskins J, Tabas L, Bright S, Shepard R, Jenkins I, et al.
Science
. 1994 Apr;
264(5157):430-3.
PMID: 8153632
The first step in oral absorption of many medically important peptide-based drugs is mediated by an intestinal proton-dependent peptide transporter. This transporter facilitates the oral absorption of beta-lactam antibiotics and...
9.
Ologunde M, Morris J, Shepard R, Afolabi A, Oke O
Plant Foods Hum Nutr
. 1994 Apr;
45(3):191-201.
PMID: 8052576
In this study, fortified and unfortified grain amaranth seed flour diets and a FeSO4-fortified casein diet (used as a control) were evaluated for their iron (Fe) bioavailability. NaFeEDTA, ferrous fumarate,...
10.
Stilmant M, Freedlund M, De las Morenas A, Shepard R, Oates R, Siroky M
Cancer
. 1989 Feb;
63(3):583-92.
PMID: 2912534
In 279 patients, 335 cytologic samples were obtained from the prostate and correlated with histology obtained by core needle biopsy in 189 cases. Approximately 6% of the cytologic specimens were...