R L Schecter
Overview
Explore the profile of R L Schecter including associated specialties, affiliations and a list of published articles.
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11
Citations
43
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Recent Articles
1.
Schecter R, Woo A, Alaoui-Jamali M, Batist G
J Biol Chem
. 2000 Aug;
275(43):33395-403.
PMID: 10934196
Persistent infection by hepatitis B virus (HBV) and exposure to chemical carcinogens correlates with the prevalence of hepatocellular carcinoma in endemic areas. The precise nature of the interaction between these...
2.
3.
Chen X, Schecter R, Griffith O, Hayward M, Alpert L, Batist G
Clin Cancer Res
. 1998 May;
4(1):131-8.
PMID: 9516961
5-Oxo-L-prolinase (5-OPase) is an enzyme of the gamma-glutamyl cycle involved in the synthesis and metabolism of glutathione (GSH), which is known to protect cells from the cytotoxic effects of chemotherapy...
4.
Alpert L, Schecter R, Berry D, Melnychuk D, Peters W, Caruso J, et al.
Clin Cancer Res
. 1997 May;
3(5):661-7.
PMID: 9815734
Glutathione S-transferase (GST) represents a multifunctional enzyme family consisting of four known cytosolic isoforms (alpha, mu, pi, and Phi) that detoxify a variety of xenobiotic chemicals and may confer resistance...
5.
Wang T, Chen X, Schecter R, Baruchel S, Melnychuk D, Batist G
J Pharmacol Exp Ther
. 1996 Mar;
276(3):1169-73.
PMID: 8786549
Glutathione (GSH) is known to play a role in cellular sensitivity to some chemotherapeutic agents and to radiation. Depletion of cellular glutathione increases toxicity of these drugs, and this approach...
6.
Greenbaum M, Letourneau S, Assar H, Schecter R, Batist G, Cournoyer D
Cancer Res
. 1994 Aug;
54(16):4442-7.
PMID: 8044793
A major limitation to successful cancer treatment is the existence of drug resistance. While several mechanisms of drug resistance have now been well characterized, mechanisms of resistance to alkylating drugs...
7.
Schecter R, Alaoui-Jamali M, Woo A, Fahl W, Batist G
Cancer Res
. 1993 Oct;
53(20):4900-6.
PMID: 8402679
The role of glutathione-S-transferase (GST) in alkylator drug resistance has been studied in MatB rat mammary carcinoma cells. A series of GST transfectant cell lines was established by using an...
8.
Alaoui-Jamali M, Schecter R, Rustum Y, Centurioni M, Lehnert S, Batist G
J Pharmacol Exp Ther
. 1993 Mar;
264(3):1299-304.
PMID: 8450465
The effectiveness of a calcium antagonist analog Ro11-2933 to modulate doxorubicin (DOX) response in DOX-sensitive (WT) and -resistant (DOXr, 200-fold) cell lines was investigated and compared to verapamil (VP) in...
9.
Schecter R, Alaoui-Jamali M, Batist G
Biochem Cell Biol
. 1992 May;
70(5):349-53.
PMID: 1353967
Cytosolic glutathione S-transferases are composed of two monomeric subunits. These monomers are the products of different gene families designated alpha, mu, and pi. Dimerization yields either homodimeric or heterodimeric holoenzymes...
10.
Schecter R, Woo A, Duong M, Batist G
Cancer Res
. 1991 Mar;
51(5):1434-42.
PMID: 1997182
Many in vitro tumor models have been examined to help understand the precise mechanisms responsible for drug resistance. The importance of these results in vivo remains uncertain. MatB 13762 is...