R L Kitchens
Overview
Explore the profile of R L Kitchens including associated specialties, affiliations and a list of published articles.
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30
Citations
710
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Recent Articles
1.
Kitchens R, Thompson P, OKeefe G, MUNFORD R
J Endotoxin Res
. 2001 Aug;
6(6):477-82.
PMID: 11521074
Innate immunity to Gram-negative bacteria involves regulated mechanisms that allow sensitive but limited responses to LPS. Two important pathways that lead to host cell activation and LPS deactivation involve: (i)...
2.
Viriyakosol S, Tobias P, Kitchens R, Kirkland T
J Biol Chem
. 2001 Aug;
276(41):38044-51.
PMID: 11500507
The exact roles and abilities of the individual components of the lipopolysaccharide (LPS) receptor complex of proteins remain unclear. MD-2 is a molecule found in association with toll-like receptor 4....
3.
Kitchens R, Thompson P, Viriyakosol S, OKeefe G, MUNFORD R
J Clin Invest
. 2001 Aug;
108(3):485-93.
PMID: 11489942
CD14, a myeloid cell-surface receptor and soluble plasma protein, binds LPS and other microbial molecules and initiates the innate immune response to bacterial invasion. The blood concentration of soluble CD14...
4.
Vesy C, Kitchens R, Wolfbauer G, Albers J, MUNFORD R
Infect Immun
. 2000 Apr;
68(5):2410-7.
PMID: 10768924
Although animals mobilize their innate defenses against gram-negative bacteria when they sense the lipid A moiety of bacterial lipopolysaccharide (LPS), excessive responses to this conserved bacterial molecule can be harmful....
5.
6.
Kitchens R, Wolfbauer G, Albers J, MUNFORD R
J Biol Chem
. 1999 Nov;
274(48):34116-22.
PMID: 10567381
When bacterial lipopolysaccharide (LPS) enters the bloodstream, it is thought to have two general fates. If LPS binds to circulating leukocytes, it triggers innate host defense mechanisms and often elicits...
7.
Kitchens R, Wang P, MUNFORD R
J Immunol
. 1998 Nov;
161(10):5534-45.
PMID: 9820530
Host recognition and disposal of LPS, an important Gram-negative bacterial signal molecule, may involve intracellular processes. We have therefore analyzed the initial pathways by which LPS, a natural ligand of...
8.
Wang P, Kitchens R, MUNFORD R
J Biol Chem
. 1998 Sep;
273(38):24309-13.
PMID: 9733716
Although bacterial lipopolysaccharides (LPS) and several other microbial agonists can bind to mCD14 (membrane CD14), a cell-surface receptor found principally on monocytes and neutrophils, host-derived mCD14 ligands are poorly defined....
9.
Sellati T, Bouis D, Kitchens R, Darveau R, Pugin J, Ulevitch R, et al.
J Immunol
. 1998 May;
160(11):5455-64.
PMID: 9605148
Lipoproteins of Treponema pallidum and Borrelia burgdorferi possess potent proinflammatory properties and, thus, have been implicated as major proinflammatory agonists in syphilis and Lyme disease. Here we used purified B....
10.
Kitchens R, MUNFORD R
J Immunol
. 1998 Feb;
160(4):1920-8.
PMID: 9469454
We analyzed the impact of ligand aggregation and LPS-induced signaling on CD14-dependent LPS internalization kinetics in human monocytic THP-1 cells and murine macrophages. Using two independent methods, we found that...