R L. Khandelwal
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Explore the profile of R L. Khandelwal including associated specialties, affiliations and a list of published articles.
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89
Citations
456
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Recent Articles
1.
Davies G, Khandelwal R, Wu L, Juurlink B, Roesler W
Biochem Pharmacol
. 2001 Oct;
62(8):1071-9.
PMID: 11597575
Phosphoenolpyruvate carboxykinase (PEPCK) is the rate-limiting enzyme of gluconeogenesis. Enhanced expression of the PEPCK gene in liver is present in most models of diabetes, and is thought to contribute to...
2.
Syed N, Khandelwal R
Mol Cell Biochem
. 2000 Oct;
211(1-2):123-36.
PMID: 11055555
The effect of insulin on glycogen synthesis and key enzymes of glycogen metabolism, glycogen phosphorylase and glycogen synthase, was studied in HepG2 cells. Insulin stimulated glycogen synthesis 1.83-3.30 fold depending...
3.
Davies G, Khandelwal R, Roesler W
Mol Cell Biol Res Commun
. 2000 Feb;
2(3):202-8.
PMID: 10662598
Troglitazone is an insulin sensitizer which affects a number of target tissues. It is believed to exert these effects primarily by binding to and activating the y-isoform of peroxisome proliferator-activated...
4.
Davies G, Khandelwal R, Roesler W
Biochim Biophys Acta
. 1999 Aug;
1451(1):122-31.
PMID: 10446394
Troglitazone is an oral insulin-sensitizing drug used to treat patients with type 2 diabetes. A major feature of this hyperglycemic state is the presence of increased rates of hepatic gluconeogenesis,...
5.
Pugazhenthi S, Khandelwal R
Mol Cell Biochem
. 1998 Jun;
182(1-2):185-91.
PMID: 9609128
Effect of the antidiabetic agent pioglitazone on the insulin-mediated activation of protein phosphatase-1 was examined in diabetic hepatocytes. Streptozotocin-induced diabetes in Sprague Dawley rats caused a significant decrease in the...
6.
Sulakhe P, Vo X, Morris T, Pato M, Khandelwal R
Mol Cell Biochem
. 1997 Nov;
175(1-2):109-15.
PMID: 9350040
The phosphorylation of rat cardiac microsomal proteins was investigated with special attention to the effects of okadaic acid (an inhibitor of protein phosphatases), inhibitor 2 of protein phosphatase 1 and...
7.
Pugazhenthi S, Tanha F, Dahl B, Khandelwal R
Arch Biochem Biophys
. 1996 Nov;
335(2):273-82.
PMID: 8914924
Inhibition of protein tyrosine phosphatase (PTP) activities by vanadate was examined in cultured rat hepatocytes. The incubation of hepatocytes with sodium orthovanadate inhibited PTP activities, measured with labeled polyglutamate tyrosine...
8.
Khandelwal R, Pugazhenthi S
Mol Cell Biochem
. 1995 Dec;
153(1-2):87-94.
PMID: 8927052
The insulin-mimetic action of vanadate is well established but the exact mechanism by which it exerts this effect is still not clearly understood. The role of insulin in the regulation...
9.
Pugazhenthi S, Hussain A, Yu B, Brownsey R, Angel J, Khandelwal R
Mol Cell Biochem
. 1995 Dec;
153(1-2):211-5.
PMID: 8927041
The effects of vanadate administration on the plasma lipids and hepatic lipogenic enzymes were investigated in Zucker (fa/fa) rat, a model for obesity and non insulin-dependent diabetes. These animals were...
10.
King M, Pugazhenthi S, Khandelwal R, Sharma R
Mol Cell Biochem
. 1995 Dec;
153(1-2):151-5.
PMID: 8927031
N-Myristoyltransferase (NMT) catalyses the transfer of myristate from myristoyl-CoA to the NH2-terminal glycine residue of several proteins and are important in signal transduction. STZ-induced diabetes (an animal model for insulin-dependent...