R Keith Humphries
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Explore the profile of R Keith Humphries including associated specialties, affiliations and a list of published articles.
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Articles
126
Citations
5577
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Recent Articles
11.
Jyotsana N, Sharma A, Chaturvedi A, Budida R, Scherr M, Kuchenbauer F, et al.
Ann Hematol
. 2019 May;
98(8):1905-1918.
PMID: 31104089
Efficient and safe delivery of siRNA in vivo is the biggest roadblock to clinical translation of RNA interference (RNAi)-based therapeutics. To date, lipid nanoparticles (LNPs) have shown efficient delivery of...
12.
Garg S, Reyes-Palomares A, He L, Bergeron A, Lavallee V, Lemieux S, et al.
Blood
. 2019 May;
134(3):263-276.
PMID: 31076446
, and are the most frequently mutated genes in cytogenetically normal acute myeloid leukemia (AML), but little is known about how these mutations synergize upon cooccurrence. Here we show that...
13.
Coulombe P, Paliouras G, Clayton A, Hussainkhel A, Fuller M, Jovanovic V, et al.
Cell Rep
. 2019 May;
27(6):1769-1780.e4.
PMID: 31067462
The sterile alpha motif (SAM) and SRC homology 3 (SH3) domain containing protein 1 (Sash1) acts as a scaffold in TLR4 signaling. We generated Sash1 mice, which die in the...
14.
Knapp D, Hammond C, Hui T, van Loenhout M, Wang F, Aghaeepour N, et al.
Nat Cell Biol
. 2018 May;
20(6):710-720.
PMID: 29802403
Elucidation of the identity and diversity of mechanisms that sustain long-term human blood cell production remains an important challenge. Previous studies indicate that, in adult mice, this property is vested...
15.
Bhayadia R, Krowiorz K, Haetscher N, Jammal R, Emmrich S, Obulkasim A, et al.
J Clin Oncol
. 2018 Feb;
36(10):1007-1016.
PMID: 29432078
Purpose Dysregulated microRNAs are implicated in the pathogenesis and aggressiveness of acute myeloid leukemia (AML). We describe the effect of the hematopoietic stem-cell self-renewal regulating miR-193b on progression and prognosis...
16.
Xiang P, Wei W, Hofs N, Clemans-Gibbon J, Maetzig T, Lai C, et al.
Blood Adv
. 2018 Jan;
1(24):2225-2235.
PMID: 29296870
Myeloid ecotropic viral integration site 1 (MEIS1), a HOX transcription cofactor, is a critical regulator of normal hematopoiesis, and its overexpression is implicated in a wide range of leukemias. Using...
17.
Schneider E, Staffas A, Rohner L, Malmberg E, Ashouri A, Krowiorz K, et al.
Haematologica
. 2017 Dec;
103(2):246-255.
PMID: 29217774
Micro-ribonucleic acid-155 (miR-155) is one of the first described oncogenic miRNAs. Although multiple direct targets of miR-155 have been identified, it is not clear how it contributes to the pathogenesis...
18.
Maetzig T, Ruschmann J, Sanchez Milde L, Lai C, von Krosigk N, Humphries R
Mol Ther Methods Clin Dev
. 2017 Jul;
6:54-65.
PMID: 28664166
Tracking the behavior of leukemic samples both in vitro and in vivo plays an increasingly large role in efforts to better understand the leukemogenic processes and the effects of potential...
19.
Mohr S, Doebele C, Comoglio F, Berg T, Beck J, Bohnenberger H, et al.
Cancer Cell
. 2017 Apr;
31(4):549-562.e11.
PMID: 28399410
The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene overexpression but is currently considered undruggable. We therefore investigated whether myeloid progenitor cells transformed by Hoxa9 and...
20.
Maetzig T, Ruschmann J, Lai C, Ngom M, Imren S, Rosten P, et al.
Mol Ther
. 2017 Mar;
25(3):606-620.
PMID: 28253481
Retroviral integration site analysis and barcoding have been instrumental for multiplex clonal fate mapping, although their use imposes an inherent delay between sample acquisition and data analysis. Monitoring of multiple...