R Karl Malcolm
Overview
Explore the profile of R Karl Malcolm including associated specialties, affiliations and a list of published articles.
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68
Citations
860
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Recent Articles
1.
Shen X, Boyd P, Dallal Bashi Y, McCoy C, Zhao R, Zhao X, et al.
Int J Pharm
. 2025 Mar;
674:125442.
PMID: 40064380
A dapivirine (DPV)-releasing vaginal ring (DapiRing®, containing 25 mg DPV) has been approved in various African countries for prevention of human immunodeficiency virus type 1 (HIV-1). Current research is focused...
2.
Friedland B, Thurman A, Nuwagaba-Biribonwoha H, Malcolm R
Front Reprod Health
. 2024 Mar;
6:1384153.
PMID: 38476596
No abstract available.
3.
Zhao X, Boyd P, Bashi Y, Murphy D, McCoy C, Coulter S, et al.
Int J Pharm
. 2023 Nov;
648:123572.
PMID: 37926178
Bacterial vaginosis (BV) is a common but often asymptomatic dysbiosis of the human vagina characterized by an imbalance in the normal vaginal microbiota due to loss of lactobacilli and an...
4.
Zhao X, Boyd P, Dallal Bashi Y, McCoy C, Malcolm R
Int J Pharm
. 2023 Aug;
644:123296.
PMID: 37553058
Bacterial vaginosis (BV) is a common dysbiosis of the human vaginal microbiota characterized by depletion of hydrogen peroxide and lactic acid-producing Lactobacillus bacteria and an overgrowth of certain facultative anaerobic...
5.
de Laat W, Pagan L, Malcolm R, Wiegerinck M, Nickolson V, Huisman B, et al.
Drug Deliv
. 2023 Feb;
30(1):2180113.
PMID: 36815245
Polymeric drug-releasing vaginal rings are useful for both local and systemic administration of drugs via the intravaginal route. Typically, they provide continuous sustained or controlled release of drug(s) over extended...
6.
Guimier E, Carson L, David B, Lambert J, Heery E, Malcolm R
J Surg Res
. 2022 Aug;
280:129-150.
PMID: 35969932
Capsular contracture is a common complication associated with breast implants following reconstructive or aesthetic surgery in which a tight or constricting scar tissue capsule forms around the implant, often distorting...
7.
Zhao X, Milford C, Smit J, Zulu B, Boyd P, Malcolm R, et al.
AIDS Behav
. 2022 Mar;
26(9):2954-2968.
PMID: 35294694
Steroid-releasing vaginal rings are available for contraception and estrogen replacement therapy, and a new antiretroviral-releasing ring was recently approved for HIV prevention. Marketed rings are white or transparent in appearance,...
8.
Murphy D, Dallal Bashi Y, McCoy C, Boyd P, Brown L, Martin F, et al.
Int J Pharm X
. 2022 Feb;
4:100112.
PMID: 35128382
We have previously reported a multipurpose silicone elastomer vaginal ring providing sustained release of dapivirine (an antiretroviral) and levonorgestrel (a progestin) for HIV prevention and hormonal contraception. During initial development,...
9.
Dallal Bashi Y, Murphy D, McCoy C, Boyd P, Brown L, Kihara M, et al.
Int J Pharm X
. 2022 Jan;
3:100091.
PMID: 34977558
A dapivirine-releasing silicone elastomer vaginal ring for reducing women's risk of HIV acquisition has recently been approved. A next-generation multipurpose vaginal ring releasing dapivirine and levonorgestrel is currently in development,...
10.
Murphy D, Lim D, Armstrong R, McCoy C, Dallal Bashi Y, Boyd P, et al.
Drug Deliv Transl Res
. 2021 Oct;
13(8):2072-2082.
PMID: 34674162
Previously reported in vitro release test methods for drug-releasing vaginal rings containing poorly water-soluble drugs have described use of water-alcohol systems or surfactant solutions in efforts to maintain sink conditions....