R Jeremy Nichols
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Explore the profile of R Jeremy Nichols including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
1596
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Recent Articles
1.
Iannotta L, Emanuele M, Favetta G, Tombesi G, Vandewynckel L, Lara Ordonez A, et al.
Front Mol Neurosci
. 2024 Jan;
16:1269387.
PMID: 38169846
Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of inherited and sporadic Parkinson's disease (PD) and previous work suggests that dephosphorylation of LRRK2 at a cluster of...
2.
Rinaldi C, Waters C, Li Z, Kumbier K, Rao L, Nichols R, et al.
Cell Rep
. 2023 May;
42(5):112447.
PMID: 37141099
Parkinson's disease-causing leucine-rich repeat kinase 2 (LRRK2) mutations lead to varying degrees of Rab GTPase hyperphosphorylation. Puzzlingly, LRRK2 GTPase-inactivating mutations-which do not affect intrinsic kinase activity-lead to higher levels of...
3.
Lesniak R, Nichols R, Montine T
Front Neurol
. 2022 Nov;
13:1016040.
PMID: 36388213
No abstract available.
4.
Lesniak R, Nichols R, Schonemann M, Zhao J, Gajera C, Lam G, et al.
Eur J Med Chem
. 2022 Sep;
242:114693.
PMID: 36049274
Mutations in the Leucine Rich Repeat Protein Kinase 2 gene (LRRK2) are genetic predispositions for Parkinson's Disease, of which the G2019S (GS) missense mutation is the most common. GS-LRRK2 has...
5.
Lesniak R, Nichols R, Schonemann M, Zhao J, Gajera C, Lam G, et al.
ACS Med Chem Lett
. 2022 Jun;
13(6):981-988.
PMID: 35707141
G2019S (GS) is the most prevalent mutation in the leucine rich repeat protein kinase 2 gene (), a genetic predisposition that is common for Parkinson's disease, as well as for...
6.
Fernandez B, Chittoor-Vinod V, Kluss J, Kelly K, Bryant N, Nguyen A, et al.
J Parkinsons Dis
. 2022 May;
12(5):1423-1447.
PMID: 35599495
Background: Coding variation in the Leucine rich repeat kinase 2 gene linked to Parkinson's disease (PD) promotes enhanced activity of the encoded LRRK2 kinase, particularly with respect to autophosphorylation at...
7.
Rideout H, Greggio E, Kortholt A, Nichols R
Front Neurosci
. 2022 Apr;
16:880914.
PMID: 35478845
No abstract available.
8.
Marchand A, Sarchione A, Athanasopoulos P, Bauderlique-Le Roy H, Goveas L, Magnez R, et al.
Cells
. 2022 Mar;
11(6).
PMID: 35326469
The () gene is a major genetic determinant of Parkinson's disease (PD), encoding a homonymous multi-domain protein with two catalytic activities, GTPase and Kinase, involved in intracellular signaling and trafficking....
9.
Stormo A, Shavarebi F, Fitzgibbon M, Earley E, Ahrendt H, Lum L, et al.
J Cell Biol
. 2022 Mar;
221(4).
PMID: 35266954
Missense mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease (PD); however, pathways regulating LRRK2 subcellular localization, function, and turnover are not fully...
10.
Lesniak R, Nichols R, Schonemann M, Zhao J, Gajera C, Fitch W, et al.
Eur J Med Chem
. 2022 Jan;
229:114080.
PMID: 34992038
Mutations in the Leucine Rich Repeat Protein Kinase 2 gene (LRRK2) are the most common genetic causes of Parkinson's Disease (PD). The G2019S mutation is the most common inherited LRRK2...