R J Zamboni
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Explore the profile of R J Zamboni including associated specialties, affiliations and a list of published articles.
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10
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327
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Recent Articles
1.
Gervais F, Xu D, Robertson G, Vaillancourt J, Zhu Y, Huang J, et al.
Cell
. 1999 May;
97(3):395-406.
PMID: 10319819
The amyloid-beta precursor protein (APP) is directly and efficiently cleaved by caspases during apoptosis, resulting in elevated amyloid-beta (A beta) peptide formation. The predominant site of caspase-mediated proteolysis is within...
2.
Gallant M, Sawyer N, Metters K, Zamboni R
Bioorg Med Chem
. 1998 Mar;
6(1):63-72.
PMID: 9502106
A novel photoaffinity probe for the leukotriene D4 receptor (LTD4) is described. L-745310, which is structurally related to the potent LTD4 antagonist MK-0476 (Singulair), was found to selectively label a...
3.
Metters K, Zamboni R
J Biol Chem
. 1993 Mar;
268(9):6487-95.
PMID: 8384212
The leukotriene (LT)D4 receptor has been defined as a G-protein-coupled receptor. In order to characterize this receptor, an iodinated, photoactivatable azido derivative of LTD4 (125I-azido-LTD4) has been synthesized for use...
4.
Nicholson D, Ali A, Vaillancourt J, Calaycay J, Mumford R, Zamboni R, et al.
Proc Natl Acad Sci U S A
. 1993 Mar;
90(5):2015-9.
PMID: 8446623
Human leukotriene C4 (LTC4) synthase was purified > 25,000-fold to homogeneity from the monocytic leukemia cell line THP-1. Beginning with taurocholate-solubilized microsomal membranes, LTC4 synthase was chromatographically resolved by (i)...
5.
Ali A, Zamboni R, Ford-Hutchinson A, Nicholson D
FEBS Lett
. 1993 Feb;
317(3):195-201.
PMID: 8425605
Human leukotriene C4 synthase specific activity in the human monocytic leukemia cell line THP-1 (0.302 +/- 0.062 nmol LTC4 formed.min-1 x mg-1) was 7.6-fold higher than in U937 cells (0.040...
6.
Nicholson D, Klemba M, Rasper D, Metters K, Zamboni R, Ford-Hutchinson A
Eur J Biochem
. 1992 Oct;
209(2):725-34.
PMID: 1425677
Human leukotriene C4 (LTC4) synthase was purified > 10000-fold from dimethylsulfoxide-differentiated U937 cells. Steps included: (a) solubilization of membrane-bound LTC4 synthase from microsomal membranes by the anionic detergent taurocholate; (b)...
7.
Grossman S, Deluca J, Zamboni R, Keenan K, Patrick D, Herold E, et al.
Toxicol Appl Pharmacol
. 1992 Oct;
116(2):217-24.
PMID: 1412466
The effects of a racemic leukotriene antagonist (MK-0571) and its component enantiomers (L-668,018 and L-668,019) on hepatic peroxisome proliferation were examined in mice, rats, and rhesus monkeys. Administration of racemic...
8.
Nicholson D, Ali A, Klemba M, Munday N, Zamboni R, Ford-Hutchinson A
J Biol Chem
. 1992 Sep;
267(25):17849-57.
PMID: 1517222
Leukotriene C4 (LTC4) synthase was highly expressed in the human U937 monoblast leukemia cell line when differentiated into monocyte/macrophage-like cells by growth in the presence of dimethyl sulfoxide. The specific...
9.
Charleson S, Evans J, Zamboni R, Leblanc Y, Fitzsimmons B, Leveille C, et al.
Prostaglandins
. 1986 Oct;
32(4):503-16.
PMID: 3025936
Specific high-affinity binding sites for [3H]-leukotriene B4 have been identified on membrane preparations from rat and human leukocytes. The rat and human leukocyte membrane preparations show linearity of binding with...
10.
Evans J, Nathaniel D, Zamboni R, Ford-Hutchinson A
J Biol Chem
. 1985 Sep;
260(20):10966-70.
PMID: 2993297
Analysis of leukotriene B4 production by purified rat and human neutrophil leukotriene (LT) A4 hydrolases in the presence of 5(S)-trans-5,6-oxido-7,9-trans-11-cis-eicosatrienoic acid (leukotriene A3) demonstrated that this epoxide is a potent...