R J Smeyne
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Explore the profile of R J Smeyne including associated specialties, affiliations and a list of published articles.
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48
Citations
2441
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Recent Articles
1.
Merlino D, Barton J, Charsar B, Byrne M, Rappaport J, Smeyne R, et al.
Brain Struct Funct
. 2019 Sep;
224(8):2983-2999.
PMID: 31485718
Guanylyl cyclase C (GUCY2C) is the afferent central receptor in the gut-brain endocrine axis regulated by the anorexigenic intestinal hormone uroguanylin. GUCY2C mRNA and protein are produced in the hypothalamus,...
2.
Smeyne M, Sladen P, Jiao Y, Dragatsis I, Smeyne R
Neuroscience
. 2015 Mar;
295:23-38.
PMID: 25796140
Exercise reduces the risk of developing a number of neurological disorders and increases the efficiency of cellular energy production. However, overly strenuous exercise produces oxidative stress. Proper oxygenation is crucial...
3.
Pattarini R, Rong Y, Shepherd K, Jiao Y, Qu C, Smeyne R, et al.
Neuroscience
. 2012 May;
214:84-105.
PMID: 22542874
Parkinson's disease (PD) is a progressive neurodegenerative disorder whose etiology is thought to have environmental (toxin) and genetic contributions. The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine (MPTP) induces pathological features of PD including loss...
4.
Baquet Z, Williams D, Brody J, Smeyne R
Neuroscience
. 2009 Apr;
161(4):1082-90.
PMID: 19376196
The substantia nigra pars compacta (SNpc) is a compact brain structure that contains a variable distribution of cells in both medial to lateral and rostral to caudal dimensions. The SNpc...
5.
Pattarini R, Smeyne R, Morgan J
Neuroscience
. 2007 Jan;
145(2):654-68.
PMID: 17258864
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). With the exception of a few rare familial forms...
6.
Lloyd S, Faherty C, Smeyne R
Neuroscience
. 2005 Nov;
137(3):905-13.
PMID: 16298078
Cocaine abuse is a significant problem in the United States, including its use by approximately 1% of pregnant women. Cocaine acts as an indirect agonist of dopamine at the dopamine...
7.
Jackson-Lewis V, Smeyne R
Neurotox Res
. 2005 May;
7(3):193-202.
PMID: 15897154
Parkinson disease (PD) is a common neurodegenerative disease of unknown origin that is characterized, mainly, by a significant reduction in the number of dopamine neurons in the substantia nigra pars...
8.
Kwon C, Zhu X, Zhang J, Knoop L, Tharp R, Smeyne R, et al.
Nat Genet
. 2001 Dec;
29(4):404-11.
PMID: 11726927
Somatic inactivation of PTEN occurs in different human tumors including glioblastoma, endometrial carcinoma and prostate carcinoma. Germline mutations in PTEN result in a range of phenotypic abnormalities that occur with...
9.
Smeyne M, Goloubeva O, Smeyne R
Glia
. 2001 Apr;
34(2):73-80.
PMID: 11307156
Parkinson's disease (PD) is a debilitating neurological disorder that strikes approximately 2% of people over age 50. Current hypotheses propose that the cause of PD is multifactorial, involving environmental agents...
10.
Chen S, Cunningham J, Smeyne R
J Recept Signal Transduct Res
. 2000 Mar;
20(1):87-103.
PMID: 10711499
In adult animals, signaling through the leptin receptor (OB-R) has been shown to play a critical role in fat metabolism. However, it is not known when these receptors are first...