R J Pickles
Overview
Explore the profile of R J Pickles including associated specialties, affiliations and a list of published articles.
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21
Citations
756
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Recent Articles
1.
Kesimer M, Ehre C, Burns K, Davis C, Sheehan J, Pickles R
Mucosal Immunol
. 2012 Aug;
6(2):379-92.
PMID: 22929560
Mucus, with its burden of inspired particulates and pathogens, is cleared from mucosal surfaces of the airways by cilia beating within the periciliary layer (PCL). The PCL is held to...
2.
McKay T, Patel M, Pickles R, Johnson L, Olsen J
Gene Ther
. 2006 Jan;
13(8):715-24.
PMID: 16397505
Lentivirus-based gene transfer has the potential to efficiently deliver DNA-based therapies into non-dividing epithelial cells of the airway for the treatment of lung diseases such as cystic fibrosis. However, significant...
3.
Pickles R
Expert Opin Investig Drugs
. 2005 Jul;
6(10):1459-63.
PMID: 15989512
Gene therapy for the treatment of the pulmonary manifestations of cystic fibrosis (CF) has been at the forefront of gene therapy research over the last several years. During this time,...
4.
Cohen C, Shieh J, Pickles R, Okegawa T, Hsieh J, Bergelson J
Proc Natl Acad Sci U S A
. 2001 Dec;
98(26):15191-6.
PMID: 11734628
The coxsackievirus and adenovirus receptor (CAR) mediates viral attachment and infection, but its physiologic functions have not been described. In nonpolarized cells, CAR localized to homotypic intercellular contacts, mediated homotypic...
5.
Israel B, Pickles R, Segal D, Gerard R, Kenney S
J Virol
. 2001 May;
75(11):5215-21.
PMID: 11333903
Although many recombinant adenovirus vectors (rAd) have been developed, especially by using group C adenoviruses, to transfer and express genes, such rAd do not readily infect B-cell lines due to...
6.
HUTCHIN M, Pickles R, Yarbrough W
Hum Gene Ther
. 2000 Nov;
11(17):2365-75.
PMID: 11096441
Adenovirus-mediated gene transfer is a novel treatment strategy for head and neck squamous cell carcinoma (HNSCC) that may improve the unacceptable morbidity and mortality associated with conventional treatment. Efficient adenoviral...
7.
Pickles R, Fahrner J, Petrella J, Boucher R, Bergelson J
J Virol
. 2000 Jun;
74(13):6050-7.
PMID: 10846088
Lumenal delivery of adenovirus vectors (AdV) results in inefficient gene transfer to human airway epithelium. The human coxsackievirus and adenovirus receptor (hCAR) was detected by immunofluorescence selectively at the basolateral...
8.
Kreda S, Pickles R, Lazarowski E, Boucher R
Nat Biotechnol
. 2000 Jun;
18(6):635-40.
PMID: 10835601
Gene therapy for cystic fibrosis (CF) has focused on correcting electrolyte transport in airway epithelia. However, success has been limited by the failure of vectors to attach and enter into...
9.
Pickles R, McCarty D, Matsui H, Hart P, Randell S, Boucher R
J Virol
. 1998 Jun;
72(7):6014-23.
PMID: 9621064
Investigations of the efficiency and safety of human adenovirus vector (AdV)-mediated gene transfer in the airways of patients with cystic fibrosis (CF) in vivo have demonstrated little success in correcting...
10.
Batra R, Olsen J, Pickles R, Hoganson D, Boucher R
Am J Respir Cell Mol Biol
. 1998 Apr;
18(3):402-10.
PMID: 9490658
Gene transfer into a panel of non-small cell lung cancer (NSCLC) cells by adenoviral (Ad) and retroviral (RV) vectors was studied. Indexed to multiplicity of infection (MOI), Ad vectors transduce...