R J Debs
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Explore the profile of R J Debs including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
534
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Recent Articles
1.
Liu Y, Liggitt D, Fong S, Debs R
Gene Ther
. 2006 Aug;
13(24):1724-30.
PMID: 16886001
Depsipeptide, a histone deacetylase (HDAC) inhibitor, kills tumor cells much more effectively than normal cells, and can produce significant antitumor activity in human cancer patients. Depsipeptide also increases the expression...
2.
Mounkes L, Zhong W, de Silva H, Handumrongkul C, Desai B, Tse E, et al.
Hum Gene Ther
. 2001 Nov;
12(16):1939-54.
PMID: 11686936
Germ line gene disruption and gene insertion are often used to study the function of selected genes in vivo. We used selected knockout and transgenic mouse models to attempt to...
3.
Meuli M, Liu Y, Liggitt D, Kashani-Sabet M, Knauer S, Meuli-Simmen C, et al.
J Invest Dermatol
. 2001 Feb;
116(1):131-5.
PMID: 11168808
Transfection of the skin by local gene delivery, as well as widespread transfection of systemic tissues following intravenous injection of cationic liposome/DNA complexes have been reported. Here, we show that...
4.
Tu G, Kirchmaier A, Liggitt D, Liu Y, Liu S, Yu W, et al.
J Biol Chem
. 2000 Jun;
275(39):30408-16.
PMID: 10856307
To date, no gene transfer vector has produced prolonged gene expression following a single intravenous injection and then efficiently re-expressed the delivered gene following repeated systemic injection into immunocompetent hosts....
5.
Gaensler K, Tu G, Bruch S, Liggitt D, Lipshutz G, Metkus A, et al.
Nat Biotechnol
. 1999 Dec;
17(12):1188-92.
PMID: 10585716
In utero injection of cationic liposome-DNA complexes (CLDCs) containing chloramphenicol acetyltransferase, beta-galactosidase (beta-gal), or human granulocyte colony-stimulating factor (hG-CSF) expression plasmids produced high-level gene expression in fetal rats. Tissues adjacent...
6.
Meuli-Simmen C, Liu Y, Yeo T, Liggitt D, Tu G, Yang T, et al.
Hum Gene Ther
. 1999 Nov;
10(16):2689-700.
PMID: 10566897
We demonstrate here that intracerebroventricular or spinal cord (intrathecal) injection of either plasmid DNA alone or cationic liposome: DNA complexes (CLDCs) produces significant levels of expression of both reporter genes...
7.
Liu Y, Thor A, Shtivelman E, Cao Y, Tu G, Heath T, et al.
J Biol Chem
. 1999 May;
274(19):13338-44.
PMID: 10224095
Cationic liposome-DNA complex (CLDC)-based intravenous gene delivery targets gene expression to vascular endothelial cells, macrophages and tumor cells. We used systemic gene delivery to identify anti-angiogenic gene products effective against...
8.
Yu W, Kashani-Sabet M, Liggitt D, Moore D, Heath T, Debs R
J Invest Dermatol
. 1999 Mar;
112(3):370-5.
PMID: 10084316
We topically applied naked plasmid DNA containing the luciferase or chloramphenicol acetyltransferase cDNA directly to mouse skin. Gene expression was detected in skin samples as early as 4 h after...
9.
Mounkes L, Zhong W, Heath T, Debs R
J Biol Chem
. 1998 Sep;
273(40):26164-70.
PMID: 9748298
The factors controlling cationic liposome-DNA complex (CLDC)-based gene transfer in cells and in animals are poorly understood. We found that cell surface heparin/heparan sulfate-bearing proteoglycans mediate CLDC-based gene transfer and...
10.
Liu Y, Mounkes L, Liggitt H, Brown C, Solodin I, Heath T, et al.
Nat Biotechnol
. 1997 Feb;
15(2):167-73.
PMID: 9035144
We have characterized the relationships between the design of cationic liposomes as a gene transfer vehicle, their resulting biodistribution and processing in animals, and the level and sites of gene...