D Papahadjopoulos
Overview
Explore the profile of D Papahadjopoulos including associated specialties, affiliations and a list of published articles.
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202
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6342
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Recent Articles
1.
Petrikovics I, Papahadjopoulos D, Hong K, Cheng T, Baskin S, Jiang J, et al.
Toxicol Sci
. 2003 Jul;
77(2):258-62.
PMID: 12857941
Prophylactic and therapeutic efficacy against organophosphorus (OP) intoxication by pralidoxime (2-PAM) and atropine were studied and compared with sterically stabilized long-circulating liposomes encapsulating recombinant organophosphorus hydrolase (OPH), either alone or...
2.
Park J, Kirpotin D, Hong K, Shalaby R, Shao Y, Nielsen U, et al.
J Control Release
. 2001 Aug;
74(1-3):95-113.
PMID: 11489487
We have generated anti-HER2 (ErbB2) immunoliposomes (ILs), consisting of long circulating liposomes linked to anti-HER2 monoclonal antibody (MAb) fragments, to provide targeted drug delivery to HER2-overexpressing cells. Immunoliposomes were constructed...
3.
Goncz K, Colosimo A, Dallapiccola B, Gagne L, Hong K, Novelli G, et al.
Gene Ther
. 2001 Jun;
8(12):961-5.
PMID: 11426337
The development of gene targeting strategies for specific modification of genomic DNA in human somatic cells has provided a potential gene therapy for the treatment of inherited diseases. One approach,...
4.
Petrikovics I, Cheng T, Papahadjopoulos D, Hong K, Yin R, Defrank J, et al.
Toxicol Sci
. 2000 Aug;
57(1):16-21.
PMID: 10966507
These studies are focused on antagonizing organophosphorous (OP) intoxications by a new conceptual approach using recombinant enzymes encapsulated within sterically stabilized liposomes to enhance diisopropylfluorophosphate (DFP) degradation. The OP hydrolyzing...
5.
Petrikovics I, McGuinn W, Sylvester D, Yuzapavik P, Jiang J, WAY J, et al.
Drug Deliv
. 2000 Jul;
7(2):83-9.
PMID: 10892408
This study describes a new approach for organophosphorous (OP) antidotal treatment by encapsulating an OP hydrolyzing enzyme, OPA anhydrolase (OPAA), within sterically stabilized liposomes. The recombinant OPAA enzyme was derived...
6.
Hong K, Kirpotin D, Park J, Shao Y, Shalaby R, Colbern G, et al.
Ann N Y Acad Sci
. 2000 Feb;
886:293-6.
PMID: 10667243
No abstract available.
7.
Drummond D, Meyer O, Hong K, Kirpotin D, Papahadjopoulos D
Pharmacol Rev
. 1999 Dec;
51(4):691-743.
PMID: 10581328
No abstract available.
8.
Petrikovics I, Hong K, Omburo G, Hu Q, Pei L, McGuinn W, et al.
Toxicol Appl Pharmacol
. 1999 Apr;
156(1):56-63.
PMID: 10101099
This investigation effort is focused on increasing organophosphate (OP) degradation by phosphotriesterase to antagonize OP intoxication. For these studies, sterically stabilized liposomes encapsulating recombinant phosphotriesterase were employed. This enzyme was...
9.
Sternberg B, Hong K, Zheng W, Papahadjopoulos D
Biochim Biophys Acta
. 1998 Oct;
1375(1-2):23-35.
PMID: 9767090
We have investigated the morphology and transfection activity of cationic liposome-DNA complexes (CLDC) under conditions relevant to both in vivo and in vitro studies. Moreover we have attempted to establish...
10.
Meyer O, Kirpotin D, Hong K, Sternberg B, Park J, Woodle M, et al.
J Biol Chem
. 1998 Jun;
273(25):15621-7.
PMID: 9624154
Modification of liposome surface with polyethylene glycol was used to improve oligodeoxyribonucleotide (ODN) loading, stability of the resulting complexes, and specificity of cellular delivery of ODN by cationic liposomes. Liposomes...