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R G Yount

Explore the profile of R G Yount including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 69
Citations 757
Followers 0
Related Specialties
Biochemistry
Science
Biophysics
Top 10 Co-Authors
J A Wells
J C Grammer
C R Cremo
E Pate
R Cooke
M M Werber
J Grammer
I Rayment
W J Perkins
Y Okamoto
Published In
Biochemistry
J Biol Chem
Proc Natl Acad Sci U S A
Methods Enzymol
Biophys J
Affiliations
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Recent Articles
1.
Synthesis and characterization of novel spin-labeled photoaffinity nonnucleoside analogues of ATP as structural and EPR probes for myosin
Chen X, Grammer J, Cooke R, Pate E, Yount R
Bioconjug Chem . 2000 Sep; 11(5):725-33. PMID: 10995217
Two new spin-labeled photoreactive nonnucleoside ATP analogues, 1-(4-azido-2-nitrophenyl)amino-3-(1-oxyl-2,2,5, 5-tetramethylpyrrolidinyl-3-carbamido)-2-propyl triphosphate (SL-NANTP) and 2-(4-azido-2-nitrophenyl)amino-2,2-(1-oxyl-2,2,6, 6-tetramethyl-4-piperidylidene)di(oxymethylene) ethyl triphosphate (SSL-NANTP), were synthesized and characterized. This study aims to develop a second generation of...
2.
Synthesis of a spin-labeled photoaffinity ATP analogue, and its use to specifically photolabel myosin cross-bridges in skeletal muscle fibers
Wang D, Luo Y, Cooke R, Grammer J, Pate E, Yount R
J Muscle Res Cell Motil . 2000 Mar; 20(8):743-53. PMID: 10730577
A spin-labeled photoaffinity ATP analogue 3'(2')-O-[4-[4-oxo-(4-amido-2,2,6,6-tetramethyl-piperidino-1-oxyl)]-benz oyl]benzoyl adenosine 5'-triphosphate (SL-Bz2ATP) was synthesized and used to photolabel myosin in muscle fibers. Previous work has shown that 3'(2')-O-(4-benzoyl)benzoyl adenosine 5'-triphosphate (Bz2ATP) photolabeled...
3.
X-ray structures of the Dictyostelium discoideum myosin motor domain with six non-nucleotide analogs
Gulick A, BAUER C, Thoden J, Pate E, Yount R, Rayment I
J Biol Chem . 2000 Jan; 275(1):398-408. PMID: 10617631
The three-dimensional structures of the truncated myosin head from Dictyostelium discoideum myosin II complexed with dinitrophenylaminoethyl-, dinitrophenylaminopropyl-, o-nitrophenylaminoethyl-, m-nitrophenylaminoethyl-, p-nitrophenylaminoethyl-, and o-nitrophenyl-N-methyl-aminoethyl-diphosphate.beryllium fluoride have been determined to better than 2.3-A...
4.
Fingerprint patterns from laser-induced azido photochemistry of spin-labeled photoaffinity ATP analogs in matrix-assisted laser desorption/ionization mass spectrometry
Chen X, Siems W, Asbury G, Yount R
J Am Soc Mass Spectrom . 1999 Dec; 10(12):1337-40. PMID: 10584330
The photochemical reaction of azide derivatives induced by ultraviolet (UV) laser in matrix-assisted laser desorption/ionization mass spectrometry (MALDI) is reported. A novel synthesized class of azide aromatic derivatives, spin-labeled photoaffinity...
5.
Conformational changes between the active-site and regulatory light chain of myosin as determined by luminescence resonance energy transfer: the effect of nucleotides and actin
Xiao M, Li H, Snyder G, Cooke R, Yount R, Selvin P
Proc Natl Acad Sci U S A . 1998 Dec; 95(26):15309-14. PMID: 9860965
Myosin is thought to generate movement of actin filaments via a conformational change between its light-chain domain and its catalytic domain that is driven by the binding of nucleotides and...
6.
Raman difference spectroscopic studies of the myosin S1.MgADP.vanadate complex
Deng H, Wang J, Callender R, Grammer J, Yount R
Biochemistry . 1998 Aug; 37(31):10972-9. PMID: 9692990
The Raman spectra of the nonbridging V--O bonds in the myosin S1.MgADP.Vi complex, often believed to be a transition-state analogue for the phosphotransfer reaction catalyzed by myosin, and in a...
7.
Chemistry and mechanism of vanadate-promoted photooxidative cleavage of myosin
Grammer J, Loo J, Edmonds C, Cremo C, Yount R
Biochemistry . 1996 Dec; 35(48):15582-92. PMID: 8952512
Irradiation of the stable myosin subfragment 1(S1).MgADP.orthovanadate (Vi) complex results in oxidation of an active site serine (Ser-180) to a serine aldehyde [Cremo, C. R., Grammer, J. C., & Yount,...
8.
The active site of myosin
Rayment I, Smith C, Yount R
Annu Rev Physiol . 1996 Jan; 58:671-702. PMID: 8815815
The significance of myosin has been expanded recently with the realization that it is found in every eukaryotic cell, where it has a role in cytokinesis, cell division, and vesicle...
9.
Is myosin a "back door" enzyme?
Yount R, Lawson D, Rayment I
Biophys J . 1995 Apr; 68(4 Suppl):44S-47S; discussion 47S-49S. PMID: 7787099
ATP has been modeled into the active site of chicken skeletal myosin subfragment-1 using the adenylate kinase.Ap5A structure as a starting reference. The resulting docked ATP.S1 structure is justified in...
10.
Photoaffinity ADP analogs as covalently attached reporter groups of the active site of myosin subfragment 1
Luo Y, Wang D, Cremo C, Pate E, Cooke R, Yount R
Biochemistry . 1995 Feb; 34(6):1978-87. PMID: 7849056
The enzymatic properties of rabbit skeletal myosin subfragment 1 (S1) have been determined after photoaffinity labeling the active site with two ADP analogs. These analogs, 2-[(4-azido-2-nitrophenyl)-amino]ethyl diphosphate (NANDP) and the...