R G Spragg
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Explore the profile of R G Spragg including associated specialties, affiliations and a list of published articles.
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Articles
67
Citations
809
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Recent Articles
1.
Spragg R, Lewis J
Am J Respir Crit Care Med
. 2001 Feb;
163(1):280-2.
PMID: 11208658
Knowledge of the surfactant system has grown immensely in the past decade. A variety of investigative strategies, including manipulation of surfactant protein gene expression in mice, has contributed dramatically to...
2.
Spragg R
Clin Chest Med
. 2000 Oct;
21(3):531-41, ix.
PMID: 11019725
Dysfunction of the surfactant system of the lung in the setting of acute lung injury (ALI) is likely to contribute to the pathophysiology of that syndrome. Multiple mechanisms, including injury...
3.
4.
Permpikul C, Wang H, Kriett J, Konopka R, Moser K, Spragg R
Respirology
. 2000 Jul;
5(2):133-40.
PMID: 10894102
Objective: To test the hypothesis that reperfusion of the canine lung after 1 week of vascular occlusion results in acute injury of the reperfused lung with concurrent impairment in gas...
5.
Spragg R, Smith R, Harris K, Lewis J, Hafner D, Germann P
J Appl Physiol (1985)
. 2000 Feb;
88(2):674-81.
PMID: 10658037
Synthetic surfactants allow examination of the effects of specific components of natural surfactant. To determine whether surfactant containing apoprotein C, dipalmitoyl-phosphatidylcholine, phosphatidylglycerol, and palmitic acid restores gas-exchanging function in acute...
6.
Spragg R, Li J
Am J Respir Cell Mol Biol
. 1999 Dec;
22(1):116-24.
PMID: 10615073
Disaturated phosphatidylcholine (DSPC) is the predominate phospholipid component of lung surfactant. In the alveolar type II cell, the cytidine diphosphocholine (CDP-choline) pathway is the major biosynthetic pathway for DSPC. To...
7.
Dresselhaus T, Luck J, WRIGHT B, Spragg R, Lee M, Bozzette S
J Gen Intern Med
. 1998 Sep;
13(8):534-40.
PMID: 9734790
Objective: To determine time allocation and the perceived value to education and patient care of the weekday activities of internal medicine housestaff on inpatient rotations and to compare the work...
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9.
Hopkins S, Schoene R, Henderson W, Spragg R, West J
J Appl Physiol (1985)
. 1998 May;
84(4):1185-9.
PMID: 9516183
The extreme thinness of the pulmonary blood-gas barrier results in high mechanical stresses in the capillary wall when the capillary pressure rises during exercise. We have previously shown that, in...
10.
Hopkins S, Schoene R, Henderson W, Spragg R, Martin T, West J
Am J Respir Crit Care Med
. 1997 Mar;
155(3):1090-4.
PMID: 9116992
The blood-gas barrier must be very thin to allow gas exchange and it is therefore subjected to high mechanical stresses when the capillary pressure rises. In some animals, such as...