R G Spragg
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Explore the profile of R G Spragg including associated specialties, affiliations and a list of published articles.
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67
Citations
809
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Recent Articles
11.
Spragg R, Smith R
Am J Respir Crit Care Med
. 1997 Feb;
155(2):756-60.
PMID: 9032225
No abstract available.
12.
Floros J, Diangelo S, Koptides M, Karinch A, Rogan P, Nielsen H, et al.
Am J Respir Cell Mol Biol
. 1996 Oct;
15(4):489-98.
PMID: 8879183
Two surfactant protein A (SP-A) genes and several alleles for each SP-A locus have been previously described. In this report we investigate the potential usefulness of the SP-A loci as...
13.
Ahuja A, Oh N, Chao W, Spragg R, Smith R
Am J Respir Cell Mol Biol
. 1996 May;
14(5):496-503.
PMID: 8624255
Production of oxygen radicals by phagocytic cells and loss of surfactant function have each been implicated in the pathogenesis of acute lung injury. Therapeutic administration of exogenous surfactant to injured...
14.
Pappert D, Gilliard N, Heldt G, Merritt T, Wagner P, Spragg R
Intensive Care Med
. 1996 Apr;
22(4):345-52.
PMID: 8708173
Objectives: To define the effect of N-nitroso-N-methyl-urethane (NNNMU) on pulmonary gas exchange, compliance and the biochemical and functional properties of the lung surfactant system. Design: Four days after inducing lung...
15.
Hastings R, Cheung T, Ditmer L, Petrin E, Burton D, Spragg R, et al.
Am J Physiol
. 1996 Mar;
270(3 Pt 1):L353-61.
PMID: 8638727
Alveolar epithelial cells in vivo, primary cultures of adult rat type II cells, and human A549 alveolar carcinoma cells express parathyroid hormone-related protein (PTHrP). Here we demonstrated that type II...
16.
Chao W, Spragg R, Smith R
J Clin Invest
. 1995 Dec;
96(6):2654-60.
PMID: 8675631
Surfactant has been shown to inhibit the production of reactive oxygen intermediates by various cells including alveolar macrophages and peripheral blood neutrophils. Superoxide O2-. production by the respiratory burst oxidase...
17.
Gilliard N, Pappert D, Spragg R
J Appl Physiol (1985)
. 1995 Mar;
78(3):862-6.
PMID: 7775330
The effect of exogenous surfactant in the treatment of acute lung injury may depend on homogeneity of distribution of the material delivered. Analyses of distribution rely on sectioning the lung,...
18.
Gilliard N, Heldt G, Loredo J, Gasser H, Redl H, Merritt T, et al.
J Clin Invest
. 1994 Jun;
93(6):2608-15.
PMID: 8200999
We have tested the hypothesis that oxidation of lung surfactant results in loss of surface tension lowering function. Porcine lung surfactant was exposed to conditions known to cause lipid peroxidation...
19.
Spragg R, Gilliard N, Richman P, Smith R, Hite R, Pappert D, et al.
Chest
. 1994 Jan;
105(1):195-202.
PMID: 8031347
In an attempt to restore functional surfactant to the lungs of patients with the adult respiratory distress syndrome (ARDS), we have treated six patients within the first 2 days of...
20.
Montisano D, Mann T, Spragg R
J Appl Physiol (1985)
. 1992 Dec;
73(6):2255-62.
PMID: 1490932
Endothelial cells subjected to cell injury are capable of producing platelet-derived growth factor (PDGF), a mitogen for the stimulation of fibroblast and smooth muscle cell proliferation. Cultured bovine pulmonary artery...