R G Korneluk
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Explore the profile of R G Korneluk including associated specialties, affiliations and a list of published articles.
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106
Citations
4019
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Recent Articles
1.
Faye M, Beug S, Graber T, Earl N, Xiang X, Wild B, et al.
Oncogene
. 2014 Apr;
34(12):1532-41.
PMID: 24704827
Rhabdomyosarcoma (RMS), a neoplasm characterised by undifferentiated myoblasts, is the most common soft tissue tumour of childhood. Although aggressive treatment of RMS could provide long-term benefit, resistance to current therapies...
2.
McComb S, Cheung H, Korneluk R, Wang S, Krishnan L, Sad S
Cell Death Differ
. 2012 May;
19(11):1791-801.
PMID: 22576661
Cellular inhibitor of apoptosis proteins (cIAPs) have emerged as important anti-cell death mediators, particularly in cancer. Although they are known to be expressed in immune tissue, their specific immune function...
3.
Cheung H, St Jean M, Beug S, Lejmi-Mrad R, LaCasse E, Baird S, et al.
Cell Death Dis
. 2011 Apr;
2:e146.
PMID: 21490678
Smac mimetic compounds (SMCs) are experimental small molecules that induce tumour necrosis factor alpha (TNFα)-dependent cancer cell death by targeting the inhibitor of apoptosis proteins. However, many cancer cell lines...
4.
LaCasse E, Mahoney D, Cheung H, Plenchette S, Baird S, Korneluk R
Oncogene
. 2008 Oct;
27(48):6252-75.
PMID: 18931692
DNA damage, chromosomal abnormalities, oncogene activation, viral infection, substrate detachment and hypoxia can all trigger apoptosis in normal cells. However, cancer cells acquire mutations that allow them to survive these...
5.
Mahoney D, Cheung H, Mrad R, Plenchette S, Simard C, Enwere E, et al.
Proc Natl Acad Sci U S A
. 2008 Aug;
105(33):11778-83.
PMID: 18697935
The cellular inhibitor of apoptosis 1 and 2 (cIAP1 and cIAP2) proteins have been implicated in the activation of NF-kappaB by TNFalpha; however, genetic deletion of either cIAP1 or 2...
6.
Surh L, Mahadevan M, Korneluk R
Curr Protoc Hum Genet
. 2008 Apr;
Chapter 9:Unit 9.6.
PMID: 18428318
Myotonic dystrophy is a genetic disorder characterized in 99% of clinically diagnosed families by an unstable CTG repeat in the 3-untranslated region of a gene encoding a serine-threonine protein kinase....
7.
Liu Z, Li H, Wu X, Yoo B, Yan S, Stadnyk A, et al.
Oncogene
. 2006 Jun;
25(59):7680-90.
PMID: 16799641
Detachment of normal epithelial cells from the extracellular matrix triggers apoptosis, a phenomenon called anoikis. Conversely, carcinoma cells tend to be relatively more anoikis-resistant than their normal counterparts, and this...
8.
Renwick J, Narang M, Coupland S, Xuan J, Baker A, Brousseau J, et al.
Gene Ther
. 2005 Nov;
13(4):339-47.
PMID: 16307001
Retinal ischemia results in the loss of vision in a number of ocular diseases including acute glaucoma, diabetic retinopathy, hypertensive retinopathy and retinal vascular occlusion. Recent studies have shown that...
9.
Crocker S, Liston P, Anisman H, Lee C, Smith P, Earl N, et al.
Neurobiol Dis
. 2003 Apr;
12(2):150-61.
PMID: 12667469
X-linked IAP protein is a potent inhibitor of cell death. Here, we describe a novel transgenic mouse in which the human XIAP gene is expressed under the control of the...
10.
Perrelet D, Ferri A, Liston P, Muzzin P, Korneluk R, Kato A
Nat Cell Biol
. 2002 Jan;
4(2):175-9.
PMID: 11813002
During embryonic development, and in certain neurodegenerative diseases, neurons die by apoptosis. A new family of anti-apoptotic proteins, termed inhibitors of apoptosis (IAP), suppresses apoptosis through the direct inhibition of...