R D Fleischmann
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Explore the profile of R D Fleischmann including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
8581
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Recent Articles
21.
Nicolaides N, Papadopoulos N, Liu B, Wei Y, Carter K, Ruben S, et al.
Nature
. 1994 Sep;
371(6492):75-80.
PMID: 8072530
Hereditary nonpolyposis colorectal cancer (HNPCC) is one of man's commonest hereditary diseases. Several studies have implicated a defect in DNA mismatch repair in the pathogenesis of this disease. In particular,...
22.
Papadopoulos N, Nicolaides N, Wei Y, Ruben S, Carter K, Rosen C, et al.
Science
. 1994 Mar;
263(5153):1625-9.
PMID: 8128251
Some cases of hereditary nonpolyposis colorectal cancer (HNPCC) are due to alterations in a mutS-related mismatch repair gene. A search of a large database of expressed sequence tags derived from...
23.
Gosse M, Padmanabhan A, Fleischmann R, Gottesman M
Proc Natl Acad Sci U S A
. 1993 Sep;
90(17):8159-63.
PMID: 8396261
The regulatory and catalytic subunits of cAMP-dependent protein kinase (PKA) were coexpressed within the same bacterial cell using a polycistronic bacterial T7 expression vector encoding Chinese hamster cDNAs for the...
24.
Thweatt R, MURANO S, Fleischmann R, Goldstein S
Exp Gerontol
. 1992 Jul;
27(4):433-40.
PMID: 1281115
No abstract available.
25.
Fleischmann R, Jeng C, Gottesman M
Somat Cell Mol Genet
. 1992 Mar;
18(2):103-11.
PMID: 1349445
We have studied the requirement for an intact cAMP-dependent protein kinase (PKA) system to regulate cAMP-mediated gene transcription in Chinese hamster ovary (CHO) cells. Wild-type CHO cells and mutant CHO...
26.
Kessin R, Fleischmann R, Gottesman M, Jastorff B, Van Lookeren Campagne M
Adv Second Messenger Phosphoprotein Res
. 1992 Jan;
25:13-27.
PMID: 1313255
No abstract available.
27.
Howard P, Day K, Kim K, Richardson J, Thomas J, Abraham I, et al.
J Biol Chem
. 1991 Jun;
266(16):10189-95.
PMID: 1645343
The mechanisms responsible for decreased levels of cAMP-dependent protein kinase activity in a mutant Chinese hamster ovary cell line have been examined. The cAMP-resistant Chinese hamster ovary 10260 cell line...
28.
Van Lookeren Campagne M, Wu E, Fleischmann R, Gottesman M, Chason K, Kessin R
J Biol Chem
. 1990 Apr;
265(10):5840-6.
PMID: 1690715
A genomic DNA fragment from Saccharomyces cerevisiae which contains the SRA5 (=PDE2) gene, coding for a low Km cAMP-phosphodiesterase, was transfected into Chinese hamster ovary cells. Clones carring the cAMP-phosphodiesterase...
29.
Gottesman M, Fleischmann R
Cancer Surv
. 1986 Jan;
5(2):291-308.
PMID: 3022924
Addition of cAMP to various cultured cell types has a dramatic effect on cell growth. Both positive and negative effects on growth have been demonstrated. Analysis of mutants with altered...
30.
Fleischmann R, Pawelek J
Proc Natl Acad Sci U S A
. 1985 Feb;
82(4):1007-11.
PMID: 2983323
Proliferation of wild-type Cloudman S91 melanoma cells is inhibited when insulin is included in the culture medium. Using growth inhibition as a selective marker, we isolated variant cell lines that...