R C Moon
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Explore the profile of R C Moon including associated specialties, affiliations and a list of published articles.
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134
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2184
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Recent Articles
1.
Gills J, Kosmeder 2nd J, Moon R, Lantvit D, Pezzuto J
J Chemother
. 2005 Jul;
17(3):297-301.
PMID: 16041863
Nonmelanoma skin cancer afflicts more than one million people in the U.S. annually, highlighting the need for more effective preventive regimens. We have investigated the ability of deguelin, a plant-derived...
2.
Christov K, Moon R, Lantvit D, Boone C, Kelloff G, Steele V, et al.
Eur J Cancer
. 2004 Jun;
40(9):1404-11.
PMID: 15177500
In most prostate chemoprevention studies conducted with animal models, the incidence and multiplicity of tumours have been used as endpoints for efficacy. However, the latency of tumours is usually over...
3.
Bhat K, Lantvit D, Christov K, Mehta R, Moon R, Pezzuto J
Cancer Res
. 2001 Oct;
61(20):7456-63.
PMID: 11606380
Trans-3,4',5-trihydroxystilbene (resveratrol), a phytoalexin present in grapes and grape products such as wine, has been identified as a chemopreventive agent. Recent studies performed with MCF-7 human breast cancer cells have...
4.
Green J, Shibata M, Shibata E, Moon R, Anver M, Kelloff G, et al.
Cancer Res
. 2001 Oct;
61(20):7449-55.
PMID: 11606379
Female transgenic mice that express SV40 T/t antigens under the regulatory control of the rat C3(1) gene spontaneously develop multifocal mammary lesions that predictably evolve into invasive, hormone-independent carcinomas, whereas...
5.
Udeani G, Zhao G, Shin Y, Kosmeder 2nd J, Beecher C, Kinghorn A, et al.
Cancer Chemother Pharmacol
. 2001 Apr;
47(3):263-8.
PMID: 11320671
Purpose: To study the pharmacokinetics of deguelin, a naturally occurring potential cancer chemopreventive agent, in rats. Methods: [3H]Deguelin was administered intravenously (i.v.) under anesthesia, and blood samples were collected over...
6.
Song L, Kosmeder 2nd J, Lee S, Gerhauser C, Lantvit D, Moon R, et al.
Cancer Res
. 1999 Feb;
59(3):578-85.
PMID: 9973203
Induction of phase II enzymes is an important mechanism of chemoprevention. In our search for novel cancer chemopreventive agents, 4'-bromoflavone (4'BF) was found to significantly induce quinone reductase (QR) activity...
7.
Moon R, Constantinou A
Breast Cancer Res Treat
. 1998 Mar;
46(2-3):181-9.
PMID: 9478273
In this review of the scientific literature the relationship between retinoids, carotenoids, and mammary carcinogenesis is examined. Several retinoids have shown promise as chemopreventive agents against chemically induced mammary carcinogenesis...
8.
Gerhauser C, Lee S, Kosmeder J, Moriarty R, Hamel E, Mehta R, et al.
Cancer Res
. 1997 Aug;
57(16):3429-35.
PMID: 9270009
Deguelin, a plant-derived rotenoid, mediates potent chemopreventive responses through transcriptional regulation of phorbol ester-induced ornithine decarboxylase (ODC) activity. To explore the mechanism of this effect, the activity of this compound...
9.
Udeani G, Gerhauser C, Thomas C, Moon R, Kosmeder J, Kinghorn A, et al.
Cancer Res
. 1997 Aug;
57(16):3424-8.
PMID: 9270008
Deguelin, a natural product isolated from Mundulea sericea (Leguminosae), was shown previously to mediate strong inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity in cell culture and to reduce the...
10.
Gerhauser C, You M, Liu J, Moriarty R, Hawthorne M, Mehta R, et al.
Cancer Res
. 1997 Jan;
57(2):272-8.
PMID: 9000567
Chemoprevention involves the use of natural or synthetic substances to reduce the risk of developing cancer. Two dietary components capable of mediating chemopreventive activity in animal models by modulation of...