R B Vallee
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Explore the profile of R B Vallee including associated specialties, affiliations and a list of published articles.
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Articles
107
Citations
5186
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Recent Articles
1.
Harms M, Ori-McKenney K, Scoto M, Tuck E, Bell S, Ma D, et al.
Neurology
. 2012 Mar;
78(22):1714-20.
PMID: 22459677
Objective: To identify the gene responsible for 14q32-linked dominant spinal muscular atrophy with lower extremity predominance (SMA-LED, OMIM 158600). Methods: Target exon capture and next generation sequencing was used to...
2.
Palazzo A, JOSEPH H, Chen Y, Dujardin D, Alberts A, Pfister K, et al.
Curr Biol
. 2001 Oct;
11(19):1536-41.
PMID: 11591323
In migrating adherent cells such as fibroblasts and endothelial cells, the microtubule-organizing center (MTOC) reorients toward the leading edge [1-3]. MTOC reorientation repositions the Golgi toward the front of the...
3.
Okamoto P, Gamby C, Wells D, Fallon J, Vallee R
J Biol Chem
. 2001 Oct;
276(51):48458-65.
PMID: 11583995
Dynamin is a GTPase involved in endocytosis and other aspects of membrane trafficking. A critical function in the presynaptic compartment attributed to the brain-specific dynamin isoform, dynamin-1, is in synaptic...
4.
Vallee R, Tai C, Faulkner N
Trends Cell Biol
. 2001 Apr;
11(4):155-60.
PMID: 11306294
Brain development is severely defective in children with lissencephaly. The highly organized distribution of neurons within the cerebral cortex is disrupted, a condition that might arise from improper migration of...
5.
Faulkner N, Dujardin D, Tai C, Vaughan K, OConnell C, Wang Y, et al.
Nat Cell Biol
. 2000 Nov;
2(11):784-91.
PMID: 11056532
Mutations in the LIS1 gene cause gross histological disorganization of the developing human brain, resulting in a brain surface that is almost smooth. Here we show that LIS1 protein co-immunoprecipitates...
6.
Tynan S, Gee M, Vallee R
J Biol Chem
. 2000 Jul;
275(42):32769-74.
PMID: 10893223
Cytoplasmic dynein is a molecular motor complex consisting of four major classes of polypeptide: the catalytic heavy chains (HC), intermediate chains (IC), light intermediate chains (LIC), and light chains (LC)....
7.
Tynan S, Purohit A, Doxsey S, Vallee R
J Biol Chem
. 2000 Jul;
275(42):32763-8.
PMID: 10893222
The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species separable by two-dimensional electrophoresis and which we...
8.
Vallee R, Faulkner N, Tai C
Biochim Biophys Acta
. 2000 Mar;
1496(1):89-98.
PMID: 10722879
Lissencephaly is a brain developmental disorder characterized by disorganization of the cortical regions resulting from defects in neuronal migration. Recent evidence has implicated the human LIS-1 gene in Miller-Dieker lissencephaly...
9.
Ye G, Vaughan K, Vallee R, Roizman B
J Virol
. 2000 Jan;
74(3):1355-63.
PMID: 10627546
To express the function encoded in its genome, the herpes simplex virus 1 capsid-tegument structure released by deenvelopment during entry into cells must be transported retrograde to the nuclear pore...
10.
Garces J, Clark I, Meyer D, Vallee R
Curr Biol
. 1999 Dec;
9(24):1497-500.
PMID: 10607597
Targeting of the minus-end directed microtubule motor cytoplasmic dynein to a wide array of intracellular substrates appears to be mediated by an accessory factor known as dynactin [1-4]. Dynactin is...