K T Vaughan
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Explore the profile of K T Vaughan including associated specialties, affiliations and a list of published articles.
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21
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1348
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Recent Articles
1.
Askham J, Vaughan K, Goodson H, Morrison E
Mol Biol Cell
. 2002 Oct;
13(10):3627-45.
PMID: 12388762
EB1 is a microtubule tip-associated protein that interacts with the APC tumor suppressor protein and components of the dynein/dynactin complex. We have found that the C-terminal 50 and 84 amino...
2.
Vaughan P, Leszyk J, Vaughan K
J Biol Chem
. 2001 May;
276(28):26171-9.
PMID: 11340075
Previously, we identified dynactin as a cargo receptor or adaptor for cytoplasmic dynein, mediated by an interaction between the dynein intermediate chain and p150(Glued). To test phosphorylation as a potential...
3.
Kennedy B, Vihtelic T, Checkley L, Vaughan K, Hyde D
J Biol Chem
. 2001 Mar;
276(17):14037-43.
PMID: 11278688
To exploit zebrafish as a transgenic model, tissue-specific promoters must be identified. We isolated a 20-kilobase (kbp) zebrafish rod opsin genomic clone, which consists of 18 kbp of 5'-flanking region,...
4.
Faulkner N, Dujardin D, Tai C, Vaughan K, OConnell C, Wang Y, et al.
Nat Cell Biol
. 2000 Nov;
2(11):784-91.
PMID: 11056532
Mutations in the LIS1 gene cause gross histological disorganization of the developing human brain, resulting in a brain surface that is almost smooth. Here we show that LIS1 protein co-immunoprecipitates...
5.
Ye G, Vaughan K, Vallee R, Roizman B
J Virol
. 2000 Jan;
74(3):1355-63.
PMID: 10627546
To express the function encoded in its genome, the herpes simplex virus 1 capsid-tegument structure released by deenvelopment during entry into cells must be transported retrograde to the nuclear pore...
6.
Fossella J, Samant S, Silver L, King S, Vaughan K, Johnson K, et al.
Mamm Genome
. 1999 Dec;
11(1):8-15.
PMID: 10602986
Poor sperm motility characterized by a distinct aberration in flagellar waveform known as "curlicue" is a hallmark of t haplotype (t) homozygous male sterility. Previous studies have localized "curlicue" and...
7.
Vaughan K, Tynan S, Faulkner N, Echeverri C, Vallee R
J Cell Sci
. 1999 Apr;
112 ( Pt 10):1437-47.
PMID: 10212138
Cytoplasmic dynein is a minus end-directed microtubule motor responsible for centripetal organelle movement and several aspects of chromosome segregation. Our search for cytoplasmic dynein-interacting proteins has implicated the dynactin complex...
8.
Steffen W, Karki S, Vaughan K, Vallee R, Holzbaur E, Weiss D, et al.
Mol Biol Cell
. 1997 Dec;
8(10):2077-88.
PMID: 9348543
Cytoplasmic dynein is one of the major motor proteins involved in intracellular transport. It is a protein complex consisting of four subunit classes: heavy chains, intermediate chains (ICs), light intermediate...
9.
Vaughan K, Mikami A, Paschal B, Holzbaur E, Hughes S, Echeverri C, et al.
Genomics
. 1996 Aug;
36(1):29-38.
PMID: 8812413
Dyneins are multisubunit mechanochemical enzymes capable of interacting with microtubules to generate force. Axonemal dyneins produce the motive force for ciliary and flagellar beating by inducing sliding between adjacent microtubules...
10.
Echeverri C, Paschal B, Vaughan K, Vallee R
J Cell Biol
. 1996 Feb;
132(4):617-33.
PMID: 8647893
Dynactin is a multi-subunit complex which has been implicated in cytoplasmic dynein function, though its mechanism of action is unknown. In this study, we have characterized the 50-kD subunit of...