R B Innis
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Explore the profile of R B Innis including associated specialties, affiliations and a list of published articles.
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133
Citations
4190
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Recent Articles
11.
van Dyck C, Soares J, Tan P, Staley J, Baldwin R, Amici L, et al.
Nucl Med Biol
. 2001 Jan;
27(8):715-22.
PMID: 11150702
[(18)F]Altanserin has emerged as a promising positron emission tomography (PET) ligand for serotonin-2A (5-HT(2A)) receptors. The deuterium substitution of both of the 2'-hydrogens of altanserin ([(18)F]deuteroaltanserin) yields a metabolically more...
12.
Fujita M, Charney D, Innis R
Biol Psychiatry
. 2000 Nov;
48(8):801-12.
PMID: 11063976
The recent development of [carbonyl-(11)C]WAY-100635 for serotonin (5-HT)(1A) and [(18)F]setoperone and [(18)F]altanserin for 5-HT(2A) positron emission tomography receptor imaging has allowed studies of 5-HT neurotransmission in depressive disorders. The hippocampus...
13.
Staley J, Tamagnan G, Baldwin R, Fujita M, Al Tikriti M, Eshima L, et al.
Nucl Med Biol
. 2000 Nov;
27(6):547-56.
PMID: 11056368
The suitability of an (123)I-labeled form of the putative D(4) receptor ligand L750,667 as a radiotracer for single photon emission computed tomography imaging was assessed in nonhuman primates. [(123)I]L750,667, labeled...
14.
JACOBSEN L, Staley J, Zoghbi S, Seibyl J, Kosten T, Innis R, et al.
Am J Psychiatry
. 2000 Sep;
157(10):1700-3.
PMID: 11007732
Objective: Evidence of a relationship between genotype and binding availability was assessed for the dopamine and serotonin transporter genes. Method: The authors assessed dopamine transporter genotype at the SLC6A3 3'...
15.
Fujita M, Tamagnan G, Zoghbi S, Baldwin R, Seibyl J, Innis R
J Nucl Med
. 2000 Sep;
41(9):1552-60.
PMID: 10994738
Unlabelled: Nicotinic acetylcholine receptors (nAChRs) play an important role in tobacco dependence and a potential therapeutic role in neuropsychiatric disorders such as Alzheimer's disease. [123I]5-iodo-3-[2(S)-2-azetidinylmethoxy]pyridine (5-I-A-85380) is a new SPECT...
16.
Tamagnan G, Baldwin R, Kula N, Baldessarini R, Innis R
Bioorg Med Chem Lett
. 2000 Sep;
10(16):1783-5.
PMID: 10969967
A series of 11 novel 3beta-substituted biphenyltropanes was synthesized and evaluated by selective radioligand binding assays for affinity to monoamine transporters. Both 5-HTT potency and selectivity for 5-HTT over DAT...
17.
Varrone A, Fujita M, Verhoeff N, Zoghbi S, Baldwin R, Rajeevan N, et al.
J Nucl Med
. 2000 Aug;
41(8):1343-51.
PMID: 10945525
Unlabelled: This study evaluated the test-retest reproducibility of D2 receptor quantification in the thalamus and temporal cortex using [123I]epidepride SPECT. Methods: Ten healthy volunteers (4 men, 6 women; age range,...
18.
van Dyck C, Malison R, Seibyl J, Laruelle M, Klumpp H, Zoghbi S, et al.
Neurobiol Aging
. 2000 Aug;
21(4):497-501.
PMID: 10924762
Postmortem studies have provided limited and conflicting data regarding aging effects on the central serotonin transporter (SERT). The present study investigated the effect of age on SERT availability in the...
19.
JACOBSEN L, Staley J, Malison R, Zoghbi S, Seibyl J, Kosten T, et al.
Am J Psychiatry
. 2000 Jun;
157(7):1134-40.
PMID: 10873923
Objective: Recent work has underscored the role of serotonergic neurotransmission in chronic neural adaptations to cocaine dependence. The authors tested for evidence of serotonergic dysfunction during acute abstinence from cocaine,...
20.
Bremner J, Innis R, Southwick S, Staib L, Zoghbi S, Charney D
Am J Psychiatry
. 2000 Jun;
157(7):1120-6.
PMID: 10873921
Objective: Animals exposed to stress exhibit a decrease in benzodiazepine receptor binding in the frontal cortex. No studies have examined central benzodiazepine receptor binding in patients with posttraumatic stress disorder...