R A Shimkets
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Explore the profile of R A Shimkets including associated specialties, affiliations and a list of published articles.
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13
Citations
1744
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Recent Articles
1.
Giot L, Bader J, Brouwer C, Chaudhuri A, Kuang B, Li Y, et al.
Science
. 2003 Nov;
302(5651):1727-36.
PMID: 14605208
Drosophila melanogaster is a proven model system for many aspects of human biology. Here we present a two-hybrid-based protein-interaction map of the fly proteome. A total of 10,623 predicted transcripts...
2.
LaRochelle W, Jeffers M, McDonald W, Chillakuru R, Giese N, Lokker N, et al.
Nat Cell Biol
. 2001 May;
3(5):517-21.
PMID: 11331882
Platelet-derived growth factor (PDGF) has been directly implicated in developmental and physiological processes, as well as in human cancer, fibrotic diseases and arteriosclerosis. The PDGF family currently consists of at...
3.
Herrmann J, Rastelli L, Burgess C, Fernandez E, Rothberg B, Rothberg J, et al.
Cancer J
. 2001 Mar;
7(1):40-51.
PMID: 11269647
The explosion of information generated by large-scale functional genomics technologies has resulted in an exponential increase in the number of potential genes and proteins available for pharmaceutical and diagnostic research...
4.
Saunders A, Trowers M, Shimkets R, Blakemore S, Crowther D, Mansfield T, et al.
Biochim Biophys Acta
. 2000 Jul;
1502(1):85-94.
PMID: 10899434
The association of inheritance of different apolipoprotein E (APOE, gene; apoE, protein) alleles with the risk and rate of onset of Alzheimer's disease (AD) is now well established and widely...
5.
Renz M, Tomlinson E, Hultgren B, Levin N, Gu Q, Shimkets R, et al.
J Biol Chem
. 2000 Apr;
275(14):10429-36.
PMID: 10744732
Absence of the hormone leptin leads to dramatic increases in appetite, food intake, and adiposity. The primary site of action, at least with respect to appetite, is the hypothalamus. Leptin...
6.
Ohneda O, Ohneda K, Nomiyama H, Zheng Z, Gold S, Arai F, et al.
Immunity
. 2000 Mar;
12(2):141-50.
PMID: 10714680
Previously, we described AGM-derived endothelial cell lines that either inhibited or permitted the development of erythroid or B cells. We utilized a differential gene expression method to isolate a chemokine,...
7.
Shimkets R, Lowe D, Tai J, Sehl P, Jin H, Yang R, et al.
Nat Biotechnol
. 1999 Aug;
17(8):798-803.
PMID: 10429247
We describe an mRNA profiling technique for determining differential gene expression that utilizes, but does not require, prior knowledge of gene sequences. This method permits high-throughput reproducible detection of most...
8.
Shimkets R, Lifton R, Canessa C
Proc Natl Acad Sci U S A
. 1998 Apr;
95(6):3301-5.
PMID: 9501257
The activity of the epithelial sodium channel (ENaC) in the distal nephron is regulated by an antidiuretic hormone, aldosterone, and insulin, but the molecular mechanisms that mediate these hormonal effects...
9.
Shimkets R, Lifton R, Canessa C
J Biol Chem
. 1997 Nov;
272(41):25537-41.
PMID: 9325269
Activity of the epithelial sodium channel (ENaC) is a key determinant of sodium homeostasis and blood pressure. Liddle's syndrome, an inherited form of hypertension, is caused by mutations that delete...
10.
Shimkets R, Lifton R
Curr Opin Nephrol Hypertens
. 1996 Mar;
5(2):162-5.
PMID: 8744539
The application of genetic strategies to studies of the pathogenesis of hypertension has proceeded on multiple fronts in the past year and has provided new insight into disease pathogenesis. Studies...