R A Sabbadini
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Explore the profile of R A Sabbadini including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
537
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Recent Articles
1.
Bouquerel P, Gstalder C, Muller D, Laurent J, Brizuela L, Sabbadini R, et al.
Oncogenesis
. 2016 Mar;
5:e209.
PMID: 26974204
The sphingosine kinase-1/sphingosine 1-phosphate (SphK1/S1P) signaling pathway has been reported to modulate the expression of the canonical transcription factor hypoxia-inducible HIF-1α in multiple cell lineages. HIF-2α is also frequently overexpressed...
2.
Krown K, Sabbadini R
Methods Mol Med
. 2011 Feb;
36:181-8.
PMID: 21340974
This chapter describes the use of cultured adult primary ventricular cardiomyocytes as a model for cytokine-mediated septic shock. We describe the methods for preparation of adult cardiomyocytes from adult rat...
3.
Sabbadini R
Br J Cancer
. 2006 Oct;
95(9):1131-5.
PMID: 17024123
This review summarises some important new findings that implicate sphingosine-1-phosphate (S1P) as a potent tumorigenic and angiogenic agent released from cancerous tumours into the tumour microenvironment. Also explored is the...
4.
Nakajima N, Cavalli A, Biral D, Glembotski C, McDonough P, Ho P, et al.
Eur J Biochem
. 2000 Sep;
267(18):5679-86.
PMID: 10971577
Recent evidence indicates that sphingolipids are produced by the heart during hypoxic stress and by blood platelets during thrombus formation. It is therefore possible that sphingolipids may influence heart cell...
5.
Sabbadini R, Danieli-Betto D, Betto R
Ital J Neurol Sci
. 2000 Aug;
20(6):423-30.
PMID: 10937863
In this review, potential roles for the endogenous sphingolipid, sphingosine, and its derivatives are described for muscle cells. Sphingosine modulates the function of important calcium channels in muscle, including the...
6.
Comstock K, Krown K, Page M, Martin D, Ho P, Pedraza M, et al.
J Mol Cell Cardiol
. 1999 Feb;
30(12):2761-75.
PMID: 9990546
The bacterial endotoxin lipopolysaccharide (LPS) contributes to the cardiovascular collapse and death observed in patients with sepsis. Because LPS has such profound effects on cardiac performance, we speculate that direct...
7.
Zechner D, Craig R, Hanford D, McDonough P, Sabbadini R, Glembotski C
J Biol Chem
. 1998 May;
273(14):8232-9.
PMID: 9525929
In cardiac myocytes the stimulation of p38 mitogen-activated protein kinase activates a hypertrophic growth program and the induction of the cardiac-specific genes associated with this program. This study focused on...
8.
Betto R, Teresi A, Turcato F, Salviati G, Sabbadini R, Krown K, et al.
Biochem J
. 1997 Feb;
322 ( Pt 1):327-33.
PMID: 9078280
Sphingosylphosphocholine (SPC) modulates Ca2+ release from isolated cardiac sarcoplasmic reticulum membranes; 50 microM SPC induces the release of 70 80% of the accumulated calcium. SPC release calcium from cardiac sarcoplasmic...
9.
Krown K, Page M, Nguyen C, Zechner D, Gutierrez V, Comstock K, et al.
J Clin Invest
. 1996 Dec;
98(12):2854-65.
PMID: 8981934
In the present study, it was shown that physiologically relevant levels of the proinflammatory cytokine TNFalpha induced apoptosis in rat cardiomyocytes in vitro, as quantified by single cell microgel electrophoresis...
10.
Krown K, Yasui K, Brooker M, Dubin A, Nguyen C, Harris G, et al.
FEBS Lett
. 1995 Nov;
376(1-2):24-30.
PMID: 8521959
Tumor necrosis factor-alpha (TNF alpha) is a potentially powerful anti-neoplastic agent; however, its therapeutic usefulness is limited by its cardiotoxic and negative inotropic effects. Accordingly, studies were undertaken to gain...