R A Franklin
Overview
Explore the profile of R A Franklin including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
94
Citations
1745
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Steelman L, Franklin R, Abrams S, Chappell W, Kempf C, Basecke J, et al.
Leukemia
. 2011 Apr;
25(7):1080-94.
PMID: 21494257
The Ras/Raf/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway is often implicated in sensitivity and resistance to leukemia therapy. Dysregulated signaling through the Ras/Raf/MEK/ERK pathway is often the result of...
2.
Steelman L, Navolanic P, Sokolosky M, Taylor J, Lehmann B, Chappell W, et al.
Oncogene
. 2008 Mar;
27(29):4086-95.
PMID: 18332865
Ectopic expression of mutant forms of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) lacking lipid (G129E) or lipid and protein (C124S) phosphatase activity decreased sensitivity of MCF-7 breast...
3.
Perry H, Franklin R, Bray S, Lo M, Svensson L, Henry S
Immunohematology
. 2008 Feb;
23(3):100-4.
PMID: 18284299
Previous studies of association of ABO blood groups with gonorrhea have shown contradictory results. Despite the interdependencies of ABO, Lewis, and secretor systems, none of the previous studies examined the...
4.
Steelman L, Pohnert S, Shelton J, Franklin R, Bertrand F, McCubrey J
Leukemia
. 2004 Jan;
18(2):189-218.
PMID: 14737178
The roles of the JAK/STAT, Raf/MEK/ERK and PI3K/Akt signal transduction pathways and the BCR-ABL oncoprotein in leukemogenesis and their importance in the regulation of cell cycle progression and apoptosis are...
5.
Shelton J, Moye P, Steelman L, Blalock W, Lee J, Franklin R, et al.
Leukemia
. 2003 Sep;
17(9):1765-82.
PMID: 12970777
The Raf/MEK/ERK and PI3K/Akt pathways regulate proliferation and prevent apoptosis, and their altered expression is commonly observed in human cancer due to the high mutation frequency of upstream regulators. In...
6.
Chang F, Steelman L, Lee J, Shelton J, Navolanic P, Blalock W, et al.
Leukemia
. 2003 Jul;
17(7):1263-93.
PMID: 12835716
The Ras/Raf/Mitogen-activated protein kinase/ERK kinase (MEK)/extracellular-signal-regulated kinase (ERK) cascade couples signals from cell surface receptors to transcription factors, which regulate gene expression. Depending upon the stimulus and cell type, this...
7.
Blalock W, Navolanic P, Steelman L, Shelton J, Moye P, Lee J, et al.
Leukemia
. 2003 May;
17(6):1058-67.
PMID: 12764369
The Raf/MEK/ERK kinase cascade plays a critical role in transducing growth signals from activated cell surface receptors. Using DeltaMEK1:ER, a conditionally active form of MEK1 which responds to either beta-estradiol...
8.
Chang F, Lee J, Navolanic P, Steelman L, Shelton J, Blalock W, et al.
Leukemia
. 2003 Mar;
17(3):590-603.
PMID: 12646949
The PI3K/Akt signal transduction cascade has been investigated extensively for its roles in oncogenic transformation. Initial studies implicated both PI3K and Akt in prevention of apoptosis. However, more recent evidence...
9.
Davis J, Navolanic P, Saleh O, Steelman L, Franklin R, Robinson P, et al.
Clin Cancer Res
. 2001 Sep;
7(9):2898-907.
PMID: 11555608
The precise molecular events involved in the development of drug resistance (DR) remain largely unknown. Raf is an intermediate in the signal transduction cascades initiated by growth factors. The hypothesis...
10.
McCubrey J, Lee J, Steelman L, Blalock W, Moye P, Chang F, et al.
Cancer Detect Prev
. 2001 Sep;
25(4):375-93.
PMID: 11531015
The PI3K/Akt and Raf/MEK/ERK signal transduction cascades are pivotal in transmitting signals from membrane receptors to downstream targets that regulate apoptosis, gene expression, and cell growth. The abilities of activated...