Quentin Defenouillere
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Explore the profile of Quentin Defenouillere including associated specialties, affiliations and a list of published articles.
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8
Citations
328
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Recent Articles
1.
Laussel C, Albanese V, Garcia-Rodriguez F, Ballin A, Defenouillere Q, Leon S
PLoS Genet
. 2022 Aug;
18(8):e1010169.
PMID: 35951639
2-deoxyglucose is a glucose analog that impacts many aspects of cellular physiology. After its uptake and its phosphorylation into 2-deoxyglucose-6-phosphate (2DG6P), it interferes with several metabolic pathways including glycolysis and...
2.
Defenouillere Q, Verraes A, Laussel C, Friedrich A, Schacherer J, Leon S
Sci Signal
. 2019 Sep;
12(597).
PMID: 31481524
Anti-cancer strategies that target the glycolytic metabolism of tumors have been proposed. The glucose analog 2-deoxyglucose (2DG) is imported into cells and, after phosphorylation, becomes 2DG-6-phosphate, a toxic by-product that...
3.
Defenouillere Q, Fromont-Racine M
Curr Genet
. 2017 May;
63(6):997-1005.
PMID: 28528489
Proteostasis in eukaryotes is maintained by compartment-specific quality control pathways, which enable the refolding or the degradation of defective polypeptides to prevent the toxicity that may arise from their aggregation....
4.
Hovsepian J, Defenouillere Q, Albanese V, Vachova L, Garcia C, Palkova Z, et al.
J Cell Biol
. 2017 May;
216(6):1811-1831.
PMID: 28468835
Nutrient availability controls the landscape of nutrient transporters present at the plasma membrane, notably by regulating their ubiquitylation and subsequent endocytosis. In yeast, this involves the Nedd4 ubiquitin ligase Rsp5...
5.
Defenouillere Q, Namane A, Mouaikel J, Jacquier A, Fromont-Racine M
Mol Biol Cell
. 2017 Mar;
28(9):1165-1176.
PMID: 28298488
Protein quality control mechanisms eliminate defective polypeptides to ensure proteostasis and to avoid the toxicity of protein aggregates. In eukaryotes, the ribosome-bound quality control (RQC) complex detects aberrant nascent peptides...
6.
Schmidt C, Kowalinski E, Shanmuganathan V, Defenouillere Q, Braunger K, Heuer A, et al.
Science
. 2016 Dec;
354(6318):1431-1433.
PMID: 27980209
Ski2-Ski3-Ski8 (Ski) is a helicase complex functioning with the RNA-degrading exosome to mediate the 3'-5' messenger RNA (mRNA) decay in turnover and quality-control pathways. We report that the Ski complex...
7.
Defenouillere Q, Zhang E, Namane A, Mouaikel J, Jacquier A, Fromont-Racine M
J Biol Chem
. 2016 Apr;
291(23):12245-53.
PMID: 27129255
Protein homeostasis is maintained by quality control mechanisms that detect and eliminate deficient translation products. Cytosolic defective proteins can arise from translation of aberrant mRNAs lacking a termination codon (NonStop)...
8.
Defenouillere Q, Yao Y, Mouaikel J, Namane A, Galopier A, Decourty L, et al.
Proc Natl Acad Sci U S A
. 2013 Mar;
110(13):5046-51.
PMID: 23479637
Ribosome stalling on eukaryotic mRNAs triggers cotranslational RNA and protein degradation through conserved mechanisms. For example, mRNAs lacking a stop codon are degraded by the exosome in association with its...