Qingyun Dan
Overview
Explore the profile of Qingyun Dan including associated specialties, affiliations and a list of published articles.
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10
Citations
160
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Recent Articles
1.
Zhan C, Lan G, Dan Q, Qin N, Pearson A, Mellinger P, et al.
Metab Eng
. 2025 Mar;
PMID: 40057262
Converting polyethylene (PE) into valuable materials, particularly ones that are better for the environment than the incumbent plastics, not only helps mitigate environmental issues caused by plastic waste but also...
2.
Englund E, Schmidt M, Nava A, Klass S, Keiser L, Dan Q, et al.
Nat Commun
. 2023 Aug;
14(1):4871.
PMID: 37573440
Type I modular polyketide synthases (PKSs) are multi-domain enzymes functioning like assembly lines. Many engineering attempts have been made for the last three decades to replace, delete and insert new...
3.
Zhan C, Lee N, Lan G, Dan Q, Cowan A, Wang Z, et al.
Nat Metab
. 2023 Jul;
5(7):1127-1140.
PMID: 37443355
Corynebacterium glutamicum is a promising host for production of valuable polyketides. Propionate addition, a strategy known to increase polyketide production by increasing intracellular methylmalonyl-CoA availability, causes growth inhibition in C. ...
4.
Huang J, Quest A, Cruz-Morales P, Deng K, Pereira J, Van Cura D, et al.
Nature
. 2023 May;
617(7960):403-408.
PMID: 37138074
Biosynthesis is an environmentally benign and renewable approach that can be used to produce a broad range of natural and, in some cases, new-to-nature products. However, biology lacks many of...
5.
Kelly S, Shende V, Flynn A, Dan Q, Ye Y, Smith J, et al.
J Am Chem Soc
. 2022 Oct;
144(42):19326-19336.
PMID: 36223664
Prenyltransfer is an early-stage carbon-hydrogen bond (C-H) functionalization prevalent in the biosynthesis of a diverse array of biologically active bacterial, fungal, plant, and metazoan diketopiperazine (DKP) alkaloids. Toward the development...
6.
Liu Y, Cruz-Morales P, Zargar A, Belcher M, Pang B, Englund E, et al.
Cell
. 2021 Feb;
184(6):1636-1647.
PMID: 33639085
Rapid increases of energy consumption and human dependency on fossil fuels have led to the accumulation of greenhouse gases and consequently, climate change. As such, major efforts have been taken...
7.
Skiba M, Tran C, Dan Q, Sikkema A, Klaver Z, Gerwick W, et al.
Structure
. 2019 Dec;
28(1):63-74.e4.
PMID: 31785925
Natural product biosynthetic pathways are replete with enzymes repurposed for new catalytic functions. In some modular polyketide synthase (PKS) pathways, a GCN5-related N-acetyltransferase (GNAT)-like enzyme with an additional decarboxylation function...
8.
Dan Q, Newmister S, Klas K, Fraley A, McAfoos T, Somoza A, et al.
Nat Chem
. 2019 Sep;
11(11):972-980.
PMID: 31548667
Prenylated indole alkaloids such as the calmodulin-inhibitory malbrancheamides and anthelmintic paraherquamides possess great structural diversity and pharmaceutical utility. Here, we report complete elucidation of the malbrancheamide biosynthetic pathway accomplished through...
9.
Skiba M, Bivins M, Schultz J, Bernard S, Fiers W, Dan Q, et al.
ACS Chem Biol
. 2018 Nov;
13(12):3221-3228.
PMID: 30489068
Modular type I polyketide synthases (PKSs) produce some of the most chemically complex metabolites in nature through a series of multienzyme modules. Each module contains a variety of catalytic domains...
10.
Skiba M, Maloney F, Dan Q, Fraley A, Aldrich C, Smith J, et al.
Methods Enzymol
. 2018 May;
604:45-88.
PMID: 29779664
The structural diversity and complexity of marine natural products have made them a rich and productive source of new bioactive molecules for drug development. The identification of these new compounds...