Qingyuan Meng
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Explore the profile of Qingyuan Meng including associated specialties, affiliations and a list of published articles.
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30
Citations
487
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Recent Articles
1.
Design, Synthesis, and Biological Evaluation of a Series of Spiro Analogues as Novel HPK1 Inhibitors
Peng J, Ding X, Chen C, Shih P, Meng Q, Ding X, et al.
ACS Med Chem Lett
. 2024 Nov;
15(11):2032-2041.
PMID: 39563821
Hematopoietic progenitor kinase 1 (HPK1) negatively affects T cell activation and proliferation and is a promising target for immunotherapy. Although HPK1 inhibitors have shown promising efficacy in preclinical models, none...
2.
Gou X, Chen Y, Ye Q, Meng Q, Jia Y, Li P, et al.
Regul Toxicol Pharmacol
. 2024 Oct;
154:105731.
PMID: 39455048
HSK21542 is a peripherally-restricted kappa opioid receptor (KOR) agonist developed for pain treatment. Because of the CNS pharmacological concern of opioid receptor activation, such as physical dependence and addiction potential,...
3.
Peng J, Ding X, Shih P, Meng Q, Ding X, Zhang M, et al.
Eur J Med Chem
. 2024 Sep;
279:116877.
PMID: 39303515
Although immune checkpoint inhibitors (ICIs) have been a revelation for treating several cancers, an unmet need remains to broaden ICI therapeutic scope and increase their response rates in clinical trials....
4.
Qi N, Pan B, Meng Q, Yang Y, Ding J, Yuan Z, et al.
BMC Med Imaging
. 2024 Sep;
24(1):236.
PMID: 39251959
Background: To evaluate the clinical performance of two deep learning methods, one utilizing real clinical pairs and the other utilizing simulated datasets, in enhancing image quality for two-dimensional (2D) fast...
5.
Pan Z, Qi N, Meng Q, Pan B, Feng T, Zhao J, et al.
Med Phys
. 2024 Apr;
51(8):5414-5426.
PMID: 38652084
Background: The application of deep learning methods in rapid bone scintigraphy is increasingly promising for minimizing the duration of SPECT examinations. Recent works showed several deep learning models based on...
6.
Niu P, Tao Y, Lin G, Xu H, Meng Q, Yang K, et al.
J Med Chem
. 2024 Apr;
67(8):6099-6118.
PMID: 38586950
The duality of function (cell cycle regulation and gene transcription) of cyclin-dependent kinase 7 (CDK7) makes it an attractive oncology target and the discovery of CDK7 inhibitors has been a...
7.
Niu P, Tao Y, Meng Q, Huang Y, Li S, Ding K, et al.
Bioorg Med Chem
. 2024 Apr;
104:117711.
PMID: 38583237
Cyclin-dependent kinase 2 (CDK2) is a member of CDK family of kinases (CDKs) that regulate the cell cycle. Its inopportune or over-activation leads to uncontrolled cell cycle progression and drives...
8.
Xu J, Ding X, Fu Y, Meng Q, Wang L, Zhang M, et al.
J Med Chem
. 2024 Jan;
67(2):1393-1405.
PMID: 38189253
Stabilization of hypoxia-inducible factor (HIF) by inhibiting prolyl hydroxylase domain enzymes (PHDs) represents a breakthrough in treating anemia associated with chronic kidney disease. Here, we identified a novel scaffold for...
9.
Qi N, Pan B, Meng Q, Yang Y, Feng T, Liu H, et al.
Phys Med Biol
. 2023 Jun;
68(13).
PMID: 37307847
. To evaluate the clinical performance of deep learning-enhanced ultrafast single photon emission computed tomography/computed tomography (SPECT/CT) bone scans in patients with suspected malignancy.. In this prospective study, 102 patients...
10.
Meng Q, Garcia-Garcia A, Dranovsky A, David Leonardo E
Sci Rep
. 2023 Feb;
13(1):3077.
PMID: 36813805
Deficits in arousal and stress responsiveness are a feature of numerous psychiatric disorders including depression and anxiety. Arousal is supported by norepinephrine (NE) released from specialized brainstem nuclei, including the...