Qingduan Wang
Overview
Explore the profile of Qingduan Wang including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
131
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Recent Articles
1.
Jing X, Niu S, Liang Y, Chen H, Wang N, Peng Y, et al.
Genes Genomics
. 2021 Oct;
44(1):123-131.
PMID: 34697761
Background: Previously, we published that 4'-azid-2'-deoxy-2'-fluorarabinoside (FNC), a novel cytosine nucleoside analog, has good anti-viral and anti-tumor activity. Objective: This study aimed to further explore the role and molecular mechanism...
2.
Wang Y, Zhuan X, Peng Y, Li Q, Huang C, Huang H, et al.
Acta Virol
. 2021 Apr;
65(1):58-67.
PMID: 33827222
Coxsackie virus B3 (CVB3) is believed to be a major cause of viral myocarditis, with virus-induced apoptosis playing an important role in pathogenesis. The purpose of this study was to...
3.
Yu F, Zhang L, Ma R, Liu C, Wang Q, Yin D
Evid Based Complement Alternat Med
. 2021 Jan;
2021:8869323.
PMID: 33505511
, a traditional Chinese medicine, has been used to treat various benign and malignant tumours for centuries in China. In our previous studies, extract (PVE) was shown to promote apoptosis...
4.
Sun L, Peng Y, Yu W, Zhang Y, Liang L, Song C, et al.
J Med Chem
. 2020 Jul;
63(15):8554-8566.
PMID: 32678592
In preclinical and phase I and II clinical studies, 2'-deoxy-2'-β-fluoro-4'-azidocytidine (FNC) displays a potent and long-lasting inhibition of HIV-1 infection. To investigate its mechanism of action, we compared it with...
5.
Zhong W, Peng Y, Yue E, Huang B, Zhang W, Zhao Z, et al.
Oral Dis
. 2019 Nov;
26(1):182-192.
PMID: 31696592
This study aims to investigate the levels of SLIT3 in gingival crevicular fluid (GCF) of healthy and periodontal disease subjects, and their correlations to periodontal disease. A total of 45...
6.
Yang W, Peng Y, Wang J, Song C, Yu W, Zhou Y, et al.
Bioorg Med Chem Lett
. 2019 Apr;
29(11):1291-1297.
PMID: 30962085
Hepatitis B virus (HBV) is a global health problem requiring more efficient and better tolerated anti-HBV agent. In this paper, a series of novel 2'-deoxy-2'-fluoro-2'-C-methyl-β-d-arabinofuranosyl 8-azanebularine analogues (1 and 2a)...
7.
Zhang J, Wang Y, Peng Y, Qin C, Liu Y, Li J, et al.
Braz J Infect Dis
. 2018 Dec;
22(6):477-486.
PMID: 30586543
Antiviral drug resistance is the most important factor contributing to treatment failure using nucleos(t)ide analogs such as lamivudine for chronic infection with hepatitis B virus (HBV). Development of a system...
8.
Liu Y, Wang Y, Peng Y, Liu B, Ma F, Jiang J, et al.
Pharmazie
. 2018 Sep;
73(9):503-507.
PMID: 30223932
The purpose of the present study was to dig into recent studies designed to characterize the impacts of 2'-deoxy-2'-β-fluoro-4'-azidocytidine (FNC) on P-glycoprotein (P-gp), multidrug resistance-associated protein 2 (MRP2) and breast...
9.
Li E, Wang Y, Yu W, Lv Z, Peng Y, Liu B, et al.
Eur J Med Chem
. 2017 Nov;
143:107-113.
PMID: 29172078
A novel β-D-2'-deoxy-2'-α-fluoro-2'-β-C-(fluoromethyl)uridine phosphoramidate prodrug (1) has been synthesized. This compound exhibits submicromolar-level antiviral activity in vitro against HCV genotypes 1b, 1a, 2a, and S282T replicons (EC = 0.18-1.13 μM)...
10.
Liu Y, Liu B, Zhang Y, Peng Y, Huang C, Wang N, et al.
Eur J Pharm Sci
. 2017 May;
105:150-158.
PMID: 28487144
2'-Deoxy-2'-β-fluoro-4'-azidocytidine (FNC), a cytidine analog, has attracted great interest because of its potent activity against wild-type and multidrug-resistant HIV. The purpose of current study was to investigate the absorption mechanisms...