Qingci Zhao
Overview
Explore the profile of Qingci Zhao including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
31
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Recent Articles
1.
Zhao Q, Shimada I, Nishida N
Methods Mol Biol
. 2024 Apr;
2797:237-252.
PMID: 38570464
The activation level of RAS can be determined by GTP hydrolysis rate (k) and GDP-GTP exchange rates (k). Either impaired GTP hydrolysis or enhanced GDP-GTP exchange causes the aberrant activation...
2.
Watanabe K, Zhao Q, Iwatsuki R, Fukui R, Ren W, Sugita Y, et al.
J Am Chem Soc
. 2024 Mar;
146(14):9790-9800.
PMID: 38549219
HDM2 negatively regulates the activity of the tumor suppressor p53. Previous NMR studies have shown that apo-HDM2 interconverts between an "open" state in which the N-terminal "lid" is disordered and...
3.
Zhao Q, Haga R, Tamura S, Shimada I, Nishida N
Sci Rep
. 2023 Nov;
13(1):19253.
PMID: 37935773
KRAS mutations are major drivers of various cancers. Recently, allele-specific inhibitors of the KRAS G12C mutant were developed that covalently modify the thiol of Cys12, thereby trapping KRAS in an...
4.
Nishide G, Lim K, Tamura M, Kobayashi A, Zhao Q, Hazawa M, et al.
J Phys Chem Lett
. 2023 Sep;
14(38):8385-8396.
PMID: 37707320
Open reading frame 6 (ORF6), the accessory protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that suppresses host type-I interferon signaling, possesses amyloidogenic sequences. ORF6 amyloidogenic peptides self-assemble to...
5.
Zhao Q, Fujimiya R, Kubo S, Marshall C, Ikura M, Shimada I, et al.
Cell Rep
. 2020 Aug;
32(8):108074.
PMID: 32846131
The small guanosine triphosphatase (GTPase) RAS serves as a molecular switch in signal transduction, and its mutation and aberrant activation are implicated in tumorigenesis. Here, we perform real-time, in-cell nuclear...
6.
Mochizuki A, Saso A, Zhao Q, Kubo S, Nishida N, Shimada I
J Am Chem Soc
. 2018 Mar;
140(10):3784-3790.
PMID: 29509009
To understand how intracellular proteins respond to oxidative stresses, the redox status of the target protein, as well as the intracellular redox potential ( E), which is defined by the...