Noritaka Nishida
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Explore the profile of Noritaka Nishida including associated specialties, affiliations and a list of published articles.
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37
Citations
1169
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Recent Articles
1.
Zhao Q, Shimada I, Nishida N
Methods Mol Biol
. 2024 Apr;
2797:237-252.
PMID: 38570464
The activation level of RAS can be determined by GTP hydrolysis rate (k) and GDP-GTP exchange rates (k). Either impaired GTP hydrolysis or enhanced GDP-GTP exchange causes the aberrant activation...
2.
Watanabe K, Zhao Q, Iwatsuki R, Fukui R, Ren W, Sugita Y, et al.
J Am Chem Soc
. 2024 Mar;
146(14):9790-9800.
PMID: 38549219
HDM2 negatively regulates the activity of the tumor suppressor p53. Previous NMR studies have shown that apo-HDM2 interconverts between an "open" state in which the N-terminal "lid" is disordered and...
3.
Zhao Q, Haga R, Tamura S, Shimada I, Nishida N
Sci Rep
. 2023 Nov;
13(1):19253.
PMID: 37935773
KRAS mutations are major drivers of various cancers. Recently, allele-specific inhibitors of the KRAS G12C mutant were developed that covalently modify the thiol of Cys12, thereby trapping KRAS in an...
4.
Nishide G, Lim K, Tamura M, Kobayashi A, Zhao Q, Hazawa M, et al.
J Phys Chem Lett
. 2023 Sep;
14(38):8385-8396.
PMID: 37707320
Open reading frame 6 (ORF6), the accessory protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that suppresses host type-I interferon signaling, possesses amyloidogenic sequences. ORF6 amyloidogenic peptides self-assemble to...
5.
Guo Y, Nishida N, Hoshino T
J Chem Inf Model
. 2021 Sep;
61(9):4571-4581.
PMID: 34565151
Ammonium sulfate (AS) and poly(ethylene glycol) (PEG) are the most popular precipitants in protein crystallization. Some proteins are preferably crystallized by AS, while some are by PEG. The electrostatic potential...
6.
Qu L, Qiao X, Qi F, Nishida N, Hoshino T
J Chem Inf Model
. 2021 May;
61(5):2396-2406.
PMID: 33934602
Antibodies are one of the most important protein molecules in biopharmaceutics. Due to the recent advance in technology for producing monoclonal antibodies, many structural data are available on the antigen-antibody...
7.
Zhao Q, Fujimiya R, Kubo S, Marshall C, Ikura M, Shimada I, et al.
Cell Rep
. 2020 Aug;
32(8):108074.
PMID: 32846131
The small guanosine triphosphatase (GTPase) RAS serves as a molecular switch in signal transduction, and its mutation and aberrant activation are implicated in tumorigenesis. Here, we perform real-time, in-cell nuclear...
8.
Nishida N, Komori Y, Takarada O, Watanabe A, Tamura S, Kubo S, et al.
Nat Commun
. 2020 Feb;
11(1):1038.
PMID: 32098965
The movements of cytoplasmic dynein on microtubule (MT) tracks is achieved by two-way communication between the microtubule-binding domain (MTBD) and the ATPase domain via a coiled-coil stalk, but the structural...
9.
Nishida N, Tsukazaki T, Kohda D
Biochim Biophys Acta Gen Subj
. 2019 Sep;
1864(2):129421.
PMID: 31491458
No abstract available.
10.
Nishida N, Ito Y, Shimada I
Biochim Biophys Acta Gen Subj
. 2019 May;
1864(2):129364.
PMID: 31103749
Background: Accumulating evidence from the experimental and computational studies indicated that the functional properties of proteins are different between in vitro and living cells, raising the necessity to examine the...