Qing-Xuan Zeng
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Explore the profile of Qing-Xuan Zeng including associated specialties, affiliations and a list of published articles.
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12
Citations
84
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Recent Articles
1.
Zeng Q, Wang K, Zhang X, Shi Y, Dou Y, Guo Z, et al.
Bioorg Chem
. 2021 Oct;
117:105432.
PMID: 34678602
Twenty-nine 12 N-substituted aloperine derivatives were synthesized and screened for suppression on PD-L1 expression in H460 cells, as a continuation of our work. Systematic structural modifications led to the identification...
2.
Wang K, Wu J, Xin-Zhang , Zeng Q, Zhang N, Huang W, et al.
Bioorg Chem
. 2021 Aug;
115:105196.
PMID: 34333425
So far, there is still no specific drug against COVID-19. Taking compound 1 with anti-EBOV activity as the lead, fifty-four 12N-substituted aloperine derivatives were synthesized and evaluated for the anti-SARS-CoV-2...
3.
Fan T, Yang Y, Zeng Q, Wang X, Wei W, Guo X, et al.
Bioorg Chem
. 2021 May;
113:104994.
PMID: 34052738
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein and its deficiency markedly enhanced the survival rate of patient with cardiovascular diseases (CVDs). Forty berberine (BBR) derivatives were synthesized...
4.
Zeng Q, Wang H, Wei W, Guo T, Yu L, Wang Y, et al.
Bioorg Chem
. 2019 Dec;
95:103490.
PMID: 31855821
A series of novel berberine (BBR) analogues were prepared and tested for their antiviral potencies against six different genotype Coxsackievirus B (CVB1-6) strains, taking BBR core for structural modification. Structure-activity...
5.
Yang Y, Lu X, Zeng Q, Pang J, Fan T, You X, et al.
Eur J Med Chem
. 2019 Mar;
168:283-292.
PMID: 30825723
A series of new 7-substituted cycloberberine (CBBR) derivatives were synthesized and evaluated for their antibacterial activities against Gram-positive pathogens, taking CBBR as the lead. The SAR revealed that the introduction...
6.
Wang Y, Yang L, Wang H, Zhao X, Liu T, Li Y, et al.
Molecules
. 2018 Aug;
23(8).
PMID: 30127288
Taking berberine (BBR) as the lead, 23 new BBR derivatives were synthesized and examined for their antiviral activities against four different genotype enterovirus 71 (EV71) strains with a cytopathic effect...
7.
Wang Y, Pang W, Zeng Q, Deng Z, Fan T, Jiang J, et al.
Eur J Med Chem
. 2017 Nov;
143:1858-1868.
PMID: 29133053
To discover small-molecule cancer immunotherapy candidates through targeting Indoleamine 2,3-dioxygenase 1 (IDO1), twenty-five new berberine (BBR) derivatives defined with substituents on position 3 or 9 were synthesized and examined for...
8.
Wang Y, Liu L, Zeng Q, Fan T, Jiang J, Deng H, et al.
Molecules
. 2017 Jul;
22(8).
PMID: 28749438
Twenty-three new berberine (BBR) analogues defined on substituents of ring D were synthesized and evaluated for their activity for suppression of tumor necrosis factor (TNF)-α-induced nuclear factor (NF)-κB activation. Structure-activity...
9.
Zhu C, Wang Y, Zeng Q, Qian Y, Li H, Yang Z, et al.
Metab Brain Dis
. 2016 Jul;
31(5):1157-64.
PMID: 27370894
Cerebral infarction disease is a severe hypoxic ischemic tissue necrosis in the brain, often leading to long-term functional disability and residual impairments. The Notch signaling pathway plays key roles in...
10.
Zhou Y, Long X, Zeng Q, Zhang C
Macromol Rapid Commun
. 2013 Mar;
34(10):883-6.
PMID: 23529840
Dissipative particle dynamics (DPD) simulations are performed to study the cooperative self-assembly of coil-rod-coil triblock copolymers and nanoparticles in solution. The results show that, when the nanoparticle concentration exceeds a...