Q R Smith
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Explore the profile of Q R Smith including associated specialties, affiliations and a list of published articles.
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68
Citations
1639
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Recent Articles
1.
Kalvass J, Polli J, Bourdet D, Feng B, Huang S, Liu X, et al.
Clin Pharmacol Ther
. 2013 Apr;
94(1):80-94.
PMID: 23588303
Drug interactions due to efflux transport inhibition at the blood-brain barrier (BBB) have been receiving increasing scrutiny because of the theoretical possibility of adverse central nervous system (CNS) effects identified...
2.
Smith Q, Nagura H
J Mol Neurosci
. 2001 Aug;
16(2-3):167-72; discussion 215-21.
PMID: 11478371
The contributions of individual components of blood to brain [14C]palmitate uptake and incorporation were studied with the in situ brain perfusion technique in the pentobarbital-anesthetized rat. With whole-blood perfusate, brain...
3.
Allen D, Smith Q
J Neurochem
. 2001 Feb;
76(4):1032-41.
PMID: 11181822
Choline enters brain by saturable transport at the blood-brain barrier (BBB). In separate studies, both sodium-dependent and passive choline transport systems of differing affinity have been reported at brain capillary...
4.
Smith Q
J Nutr
. 2000 Mar;
130(4S Suppl):1016S-22S.
PMID: 10736373
In most regions of the brain, the uptake of glutamate and other anionic excitatory amino acids from the circulation is limited by the blood-brain barrier (BBB). In most animals, the...
5.
Allen D, Smith Q
Neurosci Lett
. 2000 Jan;
277(3):198-202.
PMID: 10626847
Choline is an important membrane phospholipid constituent and a neurotransmitter precursor that is minimally synthesized in brain. The long-term maintenance of brain choline concentration is dependent on uptake from plasma,...
6.
Neuwelt E, Abbott N, Drewes L, Smith Q, Couraud P, Chiocca E, et al.
Neurosurgery
. 1999 Mar;
44(3):604-8; discussion 608-9.
PMID: 10069598
DESPITE MAJOR ADVANCES in neuroscience, potential therapeutic options for the treatment of central nervous system diseases often cannot be optimized secondary to the presence of the blood-brain barrier (BBB). During...
7.
Simpson I, Appel N, Hokari M, Oki J, Holman G, Maher F, et al.
J Neurochem
. 1999 Jan;
72(1):238-47.
PMID: 9886075
The transport of glucose across the blood-brain barrier (BBB) is mediated by the high molecular mass (55-kDa) isoform of the GLUT1 glucose transporter protein. In this study we have utilized...
8.
Allen D, Galdzicki Z, Brining S, Fukuyama R, Rapoport S, Smith Q
Neurosci Lett
. 1997 Nov;
234(1):71-3.
PMID: 9347949
Beta-amyloid peptide is the main constituent of senile plaques and is implicated in the pathogenesis of Alzheimer's disease. It has been shown to be both neurotoxic and neurotrophic in vivo,...
9.
Hokari M, Wu H, Schwarcz R, Smith Q
Neuroreport
. 1996 Dec;
8(1):15-8.
PMID: 9051744
7-Chlorokynurenic acid (7-Cl-KYNA) and 5,7-dichlorokynurenic acid (5,7-Cl2-KYNA) are of therapeutic interest as potent glycine/N-methyl-D-aspartate NMDA) receptor antagonists, but are excluded from brain by the blood-brain barrier. We examined whether these...
10.
Shetty H, Smith Q, Washizaki K, Rapoport S, Purdon A
J Neurochem
. 1996 Oct;
67(4):1702-10.
PMID: 8858956
In vivo rates of arachidonic acid incorporation and turnover were determined for molecular species of rat brain phosphatidylcholine (PtdCho) and phosphatidylinositol (PtdIns). [3H]Arachidonic acid was infused intravenously in pentobarbital-anesthetized rats...