Q R Smith
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Explore the profile of Q R Smith including associated specialties, affiliations and a list of published articles.
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68
Citations
1639
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Recent Articles
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Grange E, Deutsch J, Smith Q, Chang M, Rapoport S, Purdon A
J Neurochem
. 1995 Nov;
65(5):2290-8.
PMID: 7595518
In vivo rates of palmitate incorporation into brain phospholipids were measured in awake rats following programmed intravenous infusion of unesterified [9,10-3H]palmitate to maintain constant plasma specific activity. Animals were killed...
13.
Washizaki K, Smith Q, Rapoport S, Purdon A
J Neurochem
. 1994 Aug;
63(2):727-36.
PMID: 8035197
Brain fatty acid incorporation into phospholipids can be measured in vivo following intravenous injection of fatty acid tracer. However, to calculate a cerebral incorporation rate, knowledge is required of tracer...
14.
Rabin O, Hegedus L, Bourre J, Smith Q
J Neurochem
. 1993 Aug;
61(2):509-17.
PMID: 7687654
54Mn2+ uptake into brain and choroid plexus from the circulation was studied using the in situ rat brain perfusion technique. Initial uptake from blood was linear with time (30 s...
15.
Stoll J, Wadhwani K, Smith Q
J Neurochem
. 1993 May;
60(5):1956-9.
PMID: 8473910
Cationic amino acids are transported from blood into brain by a saturable carrier at the blood-brain barrier (BBB). The transport properties of this carrier were examined in the rat using...
16.
Smith Q
Adv Exp Med Biol
. 1993 Jan;
331:83-93.
PMID: 8333351
In summary, the results suggest that carrier-mediated transport can be used to augment the brain delivery of a wide variety of hydrophilic therapeutic drugs. A large number of carriers are...
17.
Wadhwani K, Smith Q, Rapoport S
Adv Exp Med Biol
. 1993 Jan;
331:101-6.
PMID: 8101422
No abstract available.
18.
Takada Y, Vistica D, Greig N, Purdon D, Rapoport S, Smith Q
Cancer Res
. 1992 Apr;
52(8):2191-6.
PMID: 1559223
The therapeutic efficacy of many anticancer drugs against intracerebral tumors is limited by poor uptake into the central nervous system. One way to enhance brain delivery is to design agents...
19.
Smith Q, Nagura H, Takada Y, Duncan M
J Neurochem
. 1992 Apr;
58(4):1330-7.
PMID: 1548467
beta-N-Methylamino-L-alanine (BMAA) is a neurotoxic plant amino acid that has been implicated in the pathogenesis of the high incidence amyotrophic lateral sclerosis and related parkinsonism dementia of the western Pacific....
20.
Wadhwani K, Murphy V, Smith Q, Rapoport S
Am J Physiol
. 1992 Feb;
262(2 Pt 2):R284-8.
PMID: 1539737
To determine whether the blood-nerve barrier of the rat peripheral nerve transports manganese(II) (Mn) by a saturable mechanism similar to that found at the blood-brain barrier, we measured the uptake...