Pudur Jagadeeswaran
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Explore the profile of Pudur Jagadeeswaran including associated specialties, affiliations and a list of published articles.
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61
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1104
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Recent Articles
1.
Fallatah W, Mary J, Dhinoja S, Vallabhaneni S, Jagadeeswaran P
Sci Rep
. 2025 Feb;
15(1):5180.
PMID: 39939668
Platelet production, or thrombopoiesis, is a critical process involving the differentiation of hematopoietic stem cells into megakaryocytes, which release platelets into circulation. This study employed a comprehensive screening approach through...
2.
Mary J, Jagadeeswaran P
Curr Protoc
. 2025 Feb;
5(2):e70096.
PMID: 39927620
Hemostasis is a defense mechanism for preventing fluid loss in an injured organism with a circulatory system. In mammals, it begins at the site of the injury, with platelet adhesion...
3.
Deebani A, Mary J, Dhinoja S, Al Qaryoute A, Fallatah W, Jagadeeswaran P
Sci Rep
. 2025 Jan;
15(1):3058.
PMID: 39856164
Transmembrane proteins (TMEMs) are embedded in cell membranes and often have poorly understood functions. Our RNAseq analysis identified 89 tmem genes in zebrafish thrombocytes, leading to further investigation through knockdown...
4.
Mary J, Jagadeeswaran P
Methods Mol Biol
. 2025 Jan;
2889:107-119.
PMID: 39745608
In our laboratory, we study thrombopoiesis and hemostasis using zebrafish as a model organism to unravel the mechanisms of differentiation and development of thrombocytes. We have shown in our earlier...
5.
Lekkala V, Shrestha S, Al Qaryoute A, Dhinoja S, Acharya P, Raheem A, et al.
ACS Biomater Sci Eng
. 2024 Dec;
11(1):506-517.
PMID: 39726370
Liver tissues, composed of hepatocytes, cholangiocytes, stellate cells, Kupffer cells, and sinusoidal endothelial cells, are differentiated from endodermal and mesodermal germ layers. By mimicking the developmental process of the liver,...
6.
Dhinoja S, Mary J, Al Qaryoute A, De Maria A, Jagadeeswaran P
Blood Coagul Fibrinolysis
. 2024 Dec;
36(1):26-33.
PMID: 39661534
Aim: This study aimed to create an f9l mutant zebrafish using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) and characterize its coagulation properties to investigate its functional...
7.
Fallatah W, Dhinoja S, Al Qaryoute A, Mary J, Cheng V, Jagadeeswaran P
Blood Cells Mol Dis
. 2024 Oct;
110:102897.
PMID: 39413675
In mammalian hematopoiesis, megakaryocytes mature and become polyploid in the bone marrow before releasing platelets into circulation. In contrast, fish produce thrombocytes in kidney marrow, where young thrombocytes undergo maturation...
8.
Burggren W, Abramova R, Bautista N, Fritsche Danielson R, Dubansky B, Gupta A, et al.
Biol Open
. 2024 Sep;
13(9).
PMID: 39263862
Contemporary cardiac injury models in zebrafish larvae include cryoinjury, laser ablation, pharmacological treatment and cardiac dysfunction mutations. Although effective in damaging cardiomyocytes, these models lack the important element of myocardial...
9.
Lekkala V, Shrestha S, Al Qaryoute A, Dhinoja S, Acharya P, Raheem A, et al.
bioRxiv
. 2024 Sep;
PMID: 39229042
Liver tissues, composed of hepatocytes, cholangiocytes, stellate cells, Kupffer cells, and sinusoidal endothelial cells, are differentiated from endodermal and mesodermal germ layers. By mimicking the developmental process of the liver,...
10.
Fallatah W, Mary J, Jagadeeswaran P
Methods Mol Biol
. 2024 Jul;
2812:193-201.
PMID: 39068363
Our laboratory is interested in investigating the maturation process of zebrafish thrombocytes, which are functional equivalents to human platelets. We have adopted the zebrafish model to gain insights into mammalian...