Hemalatha Sundaramoorthi
Overview
Explore the profile of Hemalatha Sundaramoorthi including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
114
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Recent Articles
1.
Dawson Z, Sundaramoorthi H, Regmi S, Zhang B, Morrison S, Fielder S, et al.
Autophagy Rep
. 2024 Jul;
3(1).
PMID: 39070663
Autophagy is important for many physiological processes; and disordered autophagy can contribute to the pathogenesis of a broad range of systemic disorders. is a useful model organism for studying the...
2.
Li J, Moretti F, Hidvegi T, Sviben S, Fitzpatrick J, Sundaramoorthi H, et al.
Cell Mol Gastroenterol Hepatol
. 2024 Feb;
17(6):1007-1024.
PMID: 38336172
Background & Aims: In the classic form of α1-antitrypsin deficiency (ATD), the misfolded α1-antitrypsin Z (ATZ) variant accumulates in the endoplasmic reticulum (ER) of liver cells. A gain-of-function proteotoxic mechanism...
3.
Sundaramoorthi H, Fallatah W, Mary J, Jagadeeswaran P
Blood Cells Mol Dis
. 2023 Sep;
104:102796.
PMID: 37717409
Thrombopoiesis is the production of platelets from megakaryocytes in the bone marrow of mammals. In fish, thrombopoiesis involves the formation of thrombocytes without megakaryocyte-like precursors but derived from erythrocyte thrombocyte...
4.
Poondru S, Joseph A, Harding J, Sundaramoorthi H, Mehta-Shah N, Green P, et al.
Case Rep Oncol
. 2023 Jan;
15(3):918-926.
PMID: 36636671
Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus. Of the approximate ten to twenty million people currently infected worldwide, 4-9% of infected individuals develop adult T-cell leukemia/lymphoma...
5.
Rauch D, Olson S, Harding J, Sundaramoorthi H, Kim Y, Zhou T, et al.
Retrovirology
. 2020 Aug;
17(1):27.
PMID: 32859220
Background: Adult T-cell leukemia lymphoma (ATLL) is a chemotherapy-resistant malignancy with a median survival of less than one year that will afflict between one hundred thousand and one million individuals...
6.
Xiang J, Rauch D, Huey D, Panfil A, Cheng X, Esser A, et al.
JCI Insight
. 2019 Oct;
4(19).
PMID: 31578308
Osteolytic bone lesions and hypercalcemia are common, serious complications in adult T cell leukemia/lymphoma (ATL), an aggressive T cell malignancy associated with human T cell leukemia virus type 1 (HTLV-1)...
7.
Rauch D, Conlon K, Janakiram M, Brammer J, Harding J, Ye B, et al.
Blood
. 2019 Aug;
134(17):1406-1414.
PMID: 31467059
Immune checkpoint inhibitors are a powerful new tool in the treatment of cancer, with prolonged responses in multiple diseases, including hematologic malignancies, such as Hodgkin lymphoma. However, in a recent...
8.
Cherian M, Olson S, Sundaramoorthi H, Cates K, Cheng X, Harding J, et al.
J Biol Chem
. 2018 Mar;
293(18):6844-6858.
PMID: 29540473
The human T-cell leukemia virus-1 (HTLV-1) oncoprotein Tax drives cell proliferation and resistance to apoptosis early in the pathogenesis of adult T-cell leukemia (ATL). Subsequently, probably as a result of...
9.
Radhakrishnan U, Alsrhani A, Sundaramoorthi H, Khandekar G, Kashyap M, Fuchs J, et al.
Platelets
. 2017 Nov;
29(8):811-820.
PMID: 29125377
Intraflagellar transport (IFT) proteins are vital for the genesis and maintenance of cilia. Our identification of ift122 transcripts in zebrafish thrombocytes that lack primary cilia was unexpected. IFT proteins serve...
10.
Sundaramoorthi H, Panapakam R, Jagadeeswaran P
Platelets
. 2015 Apr;
26(7):613-9.
PMID: 25902147
Zebrafish has become an excellent model system to study mammalian hemostasis. Despite our extensive efforts to develop technologies to measure zebrafish hemostasis and even with previously established thrombocyte qualitative and...