Priya P Karmali
Overview
Explore the profile of Priya P Karmali including associated specialties, affiliations and a list of published articles.
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20
Citations
658
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Recent Articles
1.
Milbank E, Diaz-Trelles R, Dragano N, Latorre J, Mukthavaram R, Mayneris-Perxachs J, et al.
Pharmacol Res
. 2022 Nov;
187:106562.
PMID: 36410673
Lipopolysaccharide binding protein (LBP) knockout mice models are protected against the deleterious effects of major acute inflammation but its possible physiological role has been less well studied. We aimed to...
2.
Latorre J, Diaz-Trelles R, Comas F, Gavalda-Navarro A, Milbank E, Dragano N, et al.
Mol Ther Nucleic Acids
. 2022 Sep;
29:599-613.
PMID: 36090751
Circulating lipopolysaccharide-binding protein (LBP) is increased in individuals with liver steatosis. We aimed to evaluate the possible impact of liver LBP downregulation using lipid nanoparticle-containing chemically modified LBP small interfering...
3.
Comas F, Diaz-Trelles R, Gavalda-Navarro A, Milbank E, Dragano N, Moron-Ros S, et al.
Biomed Pharmacother
. 2022 Jun;
151:113156.
PMID: 35643066
Background And Aims: The sexual dimorphism in fat-mass distribution and circulating leptin and insulin levels is well known, influencing the progression of obesity-associated metabolic disease. Here, we aimed to investigate...
4.
Diaz-Trelles R, Lee S, Kuakini K, Park J, Dukanovic A, Gonzalez J, et al.
Mol Genet Metab Rep
. 2022 May;
32:100882.
PMID: 35600090
Phenylketonuria (PKU) is a genetic disorder affecting around 1 in 12,000 live births (1), caused by a mutation in the phenylalanine hydroxylase (PAH) gene in the liver which facilitates the...
5.
Perez-Garcia C, Diaz-Trelles R, Vega J, Bao Y, Sablad M, Limphong P, et al.
Mol Ther Nucleic Acids
. 2022 Mar;
28:87-98.
PMID: 35356682
Phenylketonuria (PKU) is an inborn error caused by deficiencies in phenylalanine (Phe) metabolism. Mutations in the phenylalanine hydroxylase (PAH) gene are the main cause of the disease whose signature hallmarks...
6.
Pei Y, Bao Y, Sacchetti C, Brady J, Gillard K, Yu H, et al.
Chem Phys Lipids
. 2022 Feb;
243:105178.
PMID: 35122738
Lipid nanoparticles (LNPs) mediated mRNA delivery has gained prominence due to the success of mRNA vaccines against Covid-19, without which it would not have been possible. However, there is little...
7.
Hirunagi T, Sahashi K, Tachikawa K, Leu A, Nguyen M, Mukthavaram R, et al.
Mol Ther Nucleic Acids
. 2021 Mar;
24:1-10.
PMID: 33738134
Polyglutamine (polyQ) diseases are inherited neurodegenerative disorders caused by expansion of cytosine-adenine-guanine (CAG)-trinucleotide repeats in causative genes. These diseases include spinal and bulbar muscular atrophy (SBMA), Huntington's disease, dentatorubral-pallidoluysian atrophy,...
8.
Garu A, Moku G, Gulla S, Pramanik D, Majeti B, Karmali P, et al.
ACS Biomater Sci Eng
. 2021 Jan;
1(8):646-655.
PMID: 33435088
Herein we report on the unexpected cancer cell selective cytotoxicities of the liposomal formulations of aspartic and glutamic acid backbone-based four novel lipids with endosomal pH-sensitive head-groups and aliphatic n-hexadecyl...
9.
Perley C, Brocato R, Wu H, Bausch C, Karmali P, Vega J, et al.
Front Microbiol
. 2020 Jun;
11:832.
PMID: 32508764
We explored an emerging technology to produce anti-Hantaan virus (HTNV) and anti-Puumala virus (PUUV) neutralizing antibodies for use as pre- or post-exposure prophylactics. The technology involves hyperimmunization of transchomosomic bovines...
10.
Mucker E, Karmali P, Vega J, Kwilas S, Wu H, Joselyn M, et al.
Sci Rep
. 2020 May;
10(1):8764.
PMID: 32472093
The use of nucleic acid as a drug substance for vaccines and other gene-based medicines continues to evolve. Here, we have used a technology originally developed for mRNA in vivo...