Rajesh Mukthavaram
Overview
Explore the profile of Rajesh Mukthavaram including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
684
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Recent Articles
1.
Sawamura M, Tachikawa K, Hikawa R, Akiyama H, Kaji S, Yasuda K, et al.
Mol Ther Nucleic Acids
. 2024 Dec;
35(4):102380.
PMID: 39640012
Despite the wide range of applications of mRNA therapies, major difficulties exist in the efficient delivery of mRNA into oligodendrocytes, a type of glial cell in the brain. Commonly used...
2.
Mukthavaram R, Jiang P, Pastorino S, Nomura N, Lin F, Kesari S
Bioelectron Med
. 2024 Apr;
10(1):10.
PMID: 38594769
Background: Glioblastoma (GBM) presents as an aggressive brain cancer, notorious for its recurrence and resistance to conventional treatments. This study aimed to assess the efficacy of the EMulate Therapeutics Voyager®,...
3.
Albers S, Allen E, Bharti N, Davyt M, Joshi D, Perez-Garcia C, et al.
Nature
. 2023 May;
618(7966):842-848.
PMID: 37258671
Nonsense mutations are the underlying cause of approximately 11% of all inherited genetic diseases. Nonsense mutations convert a sense codon that is decoded by tRNA into a premature termination codon...
4.
Milbank E, Diaz-Trelles R, Dragano N, Latorre J, Mukthavaram R, Mayneris-Perxachs J, et al.
Pharmacol Res
. 2022 Nov;
187:106562.
PMID: 36410673
Lipopolysaccharide binding protein (LBP) knockout mice models are protected against the deleterious effects of major acute inflammation but its possible physiological role has been less well studied. We aimed to...
5.
Sagi A, Mukthavaram R, Recatto R, Hong H, Davis M, Trelles R, et al.
Nanomedicine (Lond)
. 2022 Oct;
17(20):1399-1410.
PMID: 36255044
To investigate the effect of incorporating bis(monoacylglycerol)phosphate (BMP) lipid into a lipid nanoparticle and the functional transport of mRNA by the formulated nanoparticles . The nanoparticles were prepared from ionizable...
6.
Latorre J, Diaz-Trelles R, Comas F, Gavalda-Navarro A, Milbank E, Dragano N, et al.
Mol Ther Nucleic Acids
. 2022 Sep;
29:599-613.
PMID: 36090751
Circulating lipopolysaccharide-binding protein (LBP) is increased in individuals with liver steatosis. We aimed to evaluate the possible impact of liver LBP downregulation using lipid nanoparticle-containing chemically modified LBP small interfering...
7.
Comas F, Diaz-Trelles R, Gavalda-Navarro A, Milbank E, Dragano N, Moron-Ros S, et al.
Biomed Pharmacother
. 2022 Jun;
151:113156.
PMID: 35643066
Background And Aims: The sexual dimorphism in fat-mass distribution and circulating leptin and insulin levels is well known, influencing the progression of obesity-associated metabolic disease. Here, we aimed to investigate...
8.
Wolff G, Sakurai M, Mhamane A, Troullinaki M, Maida A, Deligiannis I, et al.
Mol Metab
. 2022 Apr;
60:101487.
PMID: 35378329
Objective: Fibrotic organ responses have recently been identified as long-term complications in diabetes. Indeed, insulin resistance and aberrant hepatic lipid accumulation represent driving features of progressive non-alcoholic fatty liver disease...
9.
Hirunagi T, Sahashi K, Tachikawa K, Leu A, Nguyen M, Mukthavaram R, et al.
Mol Ther Nucleic Acids
. 2021 Mar;
24:1-10.
PMID: 33738134
Polyglutamine (polyQ) diseases are inherited neurodegenerative disorders caused by expansion of cytosine-adenine-guanine (CAG)-trinucleotide repeats in causative genes. These diseases include spinal and bulbar muscular atrophy (SBMA), Huntington's disease, dentatorubral-pallidoluysian atrophy,...
10.
Rajappan K, Tanis S, Mukthavaram R, Roberts S, Nguyen M, Tachikawa K, et al.
J Med Chem
. 2020 Oct;
63(21):12992-13012.
PMID: 33119286
Ionizable cationic lipids are critical components involved in nanoparticle formulations, which are utilized in delivery platforms for RNA therapeutics. While general criteria regarding lipophilicity and measured p in formulation are...