Prim B Singh
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Explore the profile of Prim B Singh including associated specialties, affiliations and a list of published articles.
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64
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2131
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Recent Articles
1.
Saliev T, Singh P
Cells
. 2025 Jan;
13(24.
PMID: 39768144
Cellular rejuvenation therapies represent a transformative frontier in addressing age-related decline and extending human health span. By targeting fundamental hallmarks of aging-such as genomic instability, epigenetic alterations, mitochondrial dysfunction, and...
2.
Gonzalez J, Bosch-Presegue L, Marazuela-Duque A, Guitart-Solanes A, Espinosa-Alcantud M, Fernandez A, et al.
Front Cell Dev Biol
. 2023 Nov;
11:1293122.
PMID: 38020886
Pericentric heterochromatin (PCH) plays an essential role in the maintenance of genome integrity and alterations in PCH have been linked to cancer and aging. HP1 α, β, and γ, are...
3.
Osipov Y, Posukh O, Kalashnikova D, Antoshina P, Laktionov P, Skrypnik P, et al.
Chromosoma
. 2023 Sep;
132(4):317-328.
PMID: 37700063
Using a new method for bulk preparation of early stage embryos, we have investigated the role played by putative Planococcus citri H3K9 and H4K20 histone methyl transferases (HMTases) in regulating...
4.
Singh P, Zhakupova A
Development
. 2022 Nov;
149(22).
PMID: 36383700
'Age reprogramming' refers to the process by which the molecular and cellular pathways of a cell that are subject to age-related decline are rejuvenated without passage through an embryonic stage....
5.
Singh P, Newman A
Epigenet Insights
. 2022 Jul;
15:25168657221109766.
PMID: 35813402
No abstract available.
6.
Le P, Ha N, Tran N, Newman A, Esselen K, Dalrymple J, et al.
Front Immunol
. 2021 Nov;
12:738958.
PMID: 34721405
Immune checkpoint blockade (ICB) relieves CD8 T-cell exhaustion in most mutated tumors, and TCF-1 is implicated in converting progenitor exhausted cells to functional effector cells. However, identifying mechanisms that can...
7.
Singh P, Belyakin S, Laktionov P
Cells
. 2020 Aug;
9(8).
PMID: 32796726
The hallmarks of constitutive heterochromatin, HP1 and H3K9me2/3, assemble heterochromatin- domains/complexes outside canonical constitutively heterochromatic territories where they regulate chromatin template-dependent processes. Domains are more than 100 kb in size;...
8.
Singh P, Newman A
R Soc Open Sci
. 2020 Apr;
7(2):191976.
PMID: 32257349
The relationship between compartmentalization of the genome and epigenetics is long and hoary. In 1928, Heitz defined heterochromatin as the largest differentiated chromatin compartment in eukaryotic nuclei. Müller's discovery of...
9.
Singh P, Laktionov P, Newman A
J Biosci
. 2019 Sep;
44(4).
PMID: 31502583
It has been proposed that age reprogramming enables old cells to be rejuvenated without passage through an embryonic stage (Singh and Zacouto in J. Biosci. 35 315-319, 2010). As such,...
10.
Singh P, Shloma V, Belyakin S
Chromosoma
. 2019 Feb;
128(2):69-80.
PMID: 30719566
Chromosomal imprinting requires an epigenetic system that "imprints" one of the two parental chromosomes such that it results in a heritable (cell-to-cell) change in behavior of the "imprinted" chromosome. Imprinting...