Prescott Leach
Overview
Explore the profile of Prescott Leach including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
3
Citations
62
Followers
0
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Related Specialties
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Recent Articles
1.
McAvoy K, Rajamohamed Sait H, Marsh G, Peterson M, Reynolds T, Gagnon J, et al.
PLoS One
. 2019 Aug;
14(8):e0220125.
PMID: 31408457
BIN1 is the most important risk locus for Late Onset Alzheimer's Disease (LOAD), after ApoE. BIN1 AD-associated SNPs correlate with Tau deposition as well as with brain atrophy. Furthermore, the...
2.
Lotfipour S, Byun J, Leach P, Fowler C, Murphy N, Kenny P, et al.
J Neurosci
. 2013 May;
33(18):7728-41.
PMID: 23637165
Baseline and nicotine-modulated behaviors were assessed in mice harboring a null mutant allele of the nicotinic acetylcholine receptor (nAChR) subunit gene α2 (Chrna2). Homozygous Chrna2(-/-) mice are viable, show expected...
3.
Mandal M, Zhu Z, Cumming J, Liu X, Strickland C, Mazzola R, et al.
J Med Chem
. 2012 Sep;
55(21):9331-45.
PMID: 22989333
On the basis of our observation that the biaryl substituent of iminopyrimidinone 7 must be in a pseudoaxial conformation to occupy the contiguous S1-S3 subsites of BACE1, we have designed...