Prenitha Mercy Ignatius Arokia Doss
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Explore the profile of Prenitha Mercy Ignatius Arokia Doss including associated specialties, affiliations and a list of published articles.
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10
Citations
137
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Recent Articles
1.
Fazazi M, Doss P, Pereira R, Fudge N, Regmi A, Joly-Beauparlant C, et al.
Nat Commun
. 2024 Jun;
15(1):5404.
PMID: 38926356
B cells and T cells collaborate in multiple sclerosis (MS) pathogenesis. IgH mice possess a B cell repertoire skewed to recognize myelin oligodendrocyte glycoprotein (MOG). Here, we show that upon...
2.
Akbar I, Tang R, Baillargeon J, Roy A, Doss P, Zhu C, et al.
J Immunol
. 2023 Nov;
211(12):1762-1766.
PMID: 37909848
Th1 cells are critical in experimental autoimmune encephalomyelitis (EAE). Serine protease inhibitor clade E1 (Serpine1) has been posited as an inhibitor of IFN-γ from T cells, although its role in...
3.
Doss P, Umair M, Baillargeon J, Fazazi R, Fudge N, Akbar I, et al.
Cell Rep
. 2021 Mar;
34(10):108833.
PMID: 33691111
Sex differences in multiple sclerosis (MS) incidence and severity have long been recognized. However, the underlying cellular and molecular mechanisms for why male sex is associated with more aggressive disease...
4.
Yeola A, Akbar I, Baillargeon J, Doss P, Paavilainen V, Rangachari M
Cytokine
. 2020 Mar;
129:154944.
PMID: 32146280
Effector CD4 T cells can be classified by the cytokines they secrete, with T helper 1 (Th1) cells generating interferon (IFN)γ and Th17 cells secreting interleukin (IL)-17. Both Th1 and...
5.
Yeola A, Doss P, Baillargeon J, Akbar I, Mailhot B, Balood M, et al.
Front Immunol
. 2020 Feb;
10:3115.
PMID: 32010149
The T cell response to central nervous system (CNS) antigen in experimental autoimmune encephalomyelitis (EAE) permits one to model the immune aspects of multiple sclerosis. 1C6 transgenic mice on the...
6.
St-Amour I, Bosoi C, Pare I, Doss P, Rangachari M, Hebert S, et al.
J Neuroinflammation
. 2019 Jan;
16(1):3.
PMID: 30611289
Background: Immunologic abnormalities have been described in peripheral blood and central nervous system of patients suffering from Alzheimer's disease (AD), yet their role in the pathogenesis still remains poorly defined....
7.
Petrin J, Fiander M, Doss P, Yeh E
Children (Basel)
. 2018 Oct;
5(11).
PMID: 30373215
Knowledge of the effect of modifiable lifestyle factors in the pediatric multiple sclerosis (MS) population is limited. We therefore conducted a scoping review, following the framework provided by Arksey and...
8.
Pare A, Mailhot B, Levesque S, Juzwik C, Doss P, Lecuyer M, et al.
Proc Natl Acad Sci U S A
. 2018 Jan;
115(6):E1194-E1203.
PMID: 29358392
Molecular interventions that limit pathogenic CNS inflammation are used to treat autoimmune conditions such as multiple sclerosis (MS). Remarkably, IL-1β-knockout mice are highly resistant to experimental autoimmune encephalomyelitis (EAE), an...
9.
Doss P, Roy A, Wang A, Anderson A, Rangachari M
Front Immunol
. 2015 Nov;
6:541.
PMID: 26557120
Multiple sclerosis (MS) is a neurodegenerative disease resulting from an autoimmune attack on central nervous system (CNS) myelin. Although CD4(+) T cell function in MS pathology has been extensively studied,...
10.
Boivin N, Baillargeon J, Doss P, Roy A, Rangachari M
PLoS One
. 2015 Apr;
10(4):e0124802.
PMID: 25885435
Interferon (IFN)-β is a front-line therapy for the treatment of the relapsing-remitting form of multiple sclerosis. However, its immunosuppressive mechanism of function remains incompletely understood. While it has been proposed...