Manu Rangachari
Overview
Explore the profile of Manu Rangachari including associated specialties, affiliations and a list of published articles.
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35
Citations
1517
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Recent Articles
1.
Bobotis B, Khakpour M, Braniff O, de Andrade E, Gargus M, Allen M, et al.
J Neuroinflammation
. 2025 Jan;
22(1):18.
PMID: 39856696
The brain presents various structural and functional sex differences, for which multiple factors are attributed: genetic, epigenetic, metabolic, and hormonal. While biological sex is determined by both sex chromosomes and...
2.
Fazazi M, Doss P, Pereira R, Fudge N, Regmi A, Joly-Beauparlant C, et al.
Nat Commun
. 2024 Jun;
15(1):5404.
PMID: 38926356
B cells and T cells collaborate in multiple sclerosis (MS) pathogenesis. IgH mice possess a B cell repertoire skewed to recognize myelin oligodendrocyte glycoprotein (MOG). Here, we show that upon...
3.
Yolmo P, Rahimi S, Chenard S, Conseil G, Jenkins D, Sachdeva K, et al.
Cancer Immunol Res
. 2024 Jun;
12(10):1320-1339.
PMID: 38916567
Poor response to Bacillus Calmette-Guérin (BCG) immunotherapy remains a major barrier in the management of patients with non-muscle invasive bladder cancer (NMIBC). Multiple factors are associated with poor outcomes, including...
4.
Zeydan B, Rangachari M, Kantarci O
Front Neurol
. 2024 Feb;
15:1366126.
PMID: 38322587
No abstract available.
5.
Akbar I, Tang R, Baillargeon J, Roy A, Doss P, Zhu C, et al.
J Immunol
. 2023 Nov;
211(12):1762-1766.
PMID: 37909848
Th1 cells are critical in experimental autoimmune encephalomyelitis (EAE). Serine protease inhibitor clade E1 (Serpine1) has been posited as an inhibitor of IFN-γ from T cells, although its role in...
6.
Fazazi M, Ruda G, Brennan P, Rangachari M
Brain Res Bull
. 2023 Sep;
202:110748.
PMID: 37657612
T cell-driven autoimmune responses are subject to striking sex-dependent effects. While the contributions of sex hormones are well-understood, those of sex chromosomes are meeting with increased appreciation. Here, we outline...
7.
Balood M, Ahmadi M, Eichwald T, Ahmadi A, Majdoubi A, Roversi K, et al.
Nature
. 2022 Nov;
611(7935):405-412.
PMID: 36323780
Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory peripheral nervous systems. Whether the neo-innervation of tumours by pain-initiating sensory neurons affects cancer immunosurveillance remains...
8.
MacDougall M, El-Hajj Sleiman J, Beauchemin P, Rangachari M
Front Immunol
. 2022 May;
13:871276.
PMID: 35572514
While the respiratory tract is the primary route of entry for SARS-CoV-2, evidence shows that the virus also impacts the central nervous system. Intriguingly, case reports have documented SARS-CoV-2 patients...
9.
Dore E, Joly-Beauparlant C, Morozumi S, Mathieu A, Levesque T, Allaeys I, et al.
JCI Insight
. 2022 Jan;
7(2).
PMID: 35076027
Secreted phospholipase A2-IIA (sPLA2-IIA) hydrolyzes phospholipids to liberate lysophospholipids and fatty acids. Given its poor activity toward eukaryotic cell membranes, its role in the generation of proinflammatory lipid mediators is...
10.
Umair M, Fazazi M, Rangachari M
Antioxid Redox Signal
. 2021 Sep;
37(1-3):135-149.
PMID: 34538129
T cells play a pivotal role in maintaining adaptive immune responses against pathogens. However, misdirected T cell responses against self-tissues may lead to autoimmune disease. Biological sex has profound effects...