Premlata Shankar
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Explore the profile of Premlata Shankar including associated specialties, affiliations and a list of published articles.
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47
Citations
3141
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Recent Articles
11.
Choi J, Bharaj P, Abraham S, Ma H, Yi G, Ye C, et al.
Mol Ther
. 2014 Nov;
23(2):310-20.
PMID: 25358251
Multiplexed miRNA-based shRNAs (shRNA-miRs) could have wide potential to simultaneously suppress multiple genes. Here, we describe a simple strategy to express a large number of shRNA-miRs using minimal flanking sequences...
12.
Bharaj P, Chahar H, Alozie O, Rodarte L, Bansal A, Goepfert P, et al.
PLoS One
. 2014 Oct;
9(10):e109103.
PMID: 25279955
Chronic immune activation that persists despite anti-retroviral therapy (ART) is the strongest predictor of disease progression in HIV infection. Monocyte/macrophages in HIV-infected individuals are known to spontaneously secrete cytokines, although...
13.
Ye C, Choi J, Abraham S, Shankar P, Manjunath N
Eur J Immunol
. 2014 Oct;
45(1):82-8.
PMID: 25270431
Targeting DNA vaccines to dendritic cells (DCs) greatly enhances immunity. Although several approaches have been used to target protein Ags to DCs, currently there is no method that targets DNA...
14.
Yi G, Choi J, Bharaj P, Abraham S, Dang Y, Kafri T, et al.
Mol Ther Nucleic Acids
. 2014 Oct;
3:e198.
PMID: 25268698
CCR5 disruption by zinc finger nucleases (ZFNs) is a promising method for HIV-1 gene therapy. However, successful clinical translation of this strategy necessitates the development of a safe and effective...
15.
Manjunath N, Yi G, Dang Y, Shankar P
Viruses
. 2013 Nov;
5(11):2748-66.
PMID: 24284874
Despite the great success of highly active antiretroviral therapy (HAART) in ameliorating the course of HIV infection, alternative therapeutic approaches are being pursued because of practical problems associated with life-long...
16.
Abraham S, Pahwa R, Ye C, Choi J, Pahwa S, Jaggaiahgari S, et al.
PLoS One
. 2012 Dec;
7(12):e51832.
PMID: 23272176
Regulatory T cells are essential to maintain immune homeostasis and prevent autoimmunity. Therapy with in vitro expanded human nT(Regs) is being tested to prevent graft versus host disease, which is...
17.
Ye C, Choi J, Abraham S, Wu H, Diaz D, Terreros D, et al.
Proc Natl Acad Sci U S A
. 2012 Dec;
109(51):21052-7.
PMID: 23213216
Hypersecretion of cytokines by innate immune cells is thought to initiate multiple organ failure in murine models of sepsis. Whether human cytokine storm also plays a similar role is not...
18.
Wu H, Ma H, Ye C, Ramirez D, Chen S, Montoya J, et al.
PLoS One
. 2011 Dec;
6(12):e28580.
PMID: 22174840
siRNA (small interfering RNA) and shRNA (small hairpin RNA) are powerful and commonly used tools in biomedical research. Currently, siRNAs are generally designed as two 21 nt strands of RNA...
19.
Kim S, Kumar P, Ye C, Shankar P
Methods Mol Biol
. 2011 Sep;
757:509-21.
PMID: 21909931
Humanized mice have recently emerged as powerful translational animal models for studying human hematopoiesis, immune interactions, and diseases of the human immune system. Several important advances in the humanized mouse...
20.
Joshi A, Garg H, Ablan S, Freed E, Nagashima K, Manjunath N, et al.
Virology
. 2011 May;
415(2):95-106.
PMID: 21529874
Targeting the HIV entry and assembly pathways holds promise for development of novel anti-HIV gene therapy vectors. We characterized discrete dominant negative (DN) Gag and Envelope mutants for their anti-HIV-1...