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Prema M Nair

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Articles 19
Citations 559
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Recent Articles
1.
Liu G, Hsu A, Geirnaert S, Cong C, Nair P, Shen S, et al.
Mol Ther . 2025 Jan; 33(3):917-932. PMID: 39838644
Vitronectin (VTN) is an important extracellular matrix protein in tissue remodeling, but its role in chronic obstructive pulmonary disease (COPD) is unknown. We show that VTN regulates tissue remodeling through...
2.
Liu G, Haw T, Starkey M, Philp A, Pavlidis S, Nalkurthi C, et al.
Nat Commun . 2023 Nov; 14(1):7349. PMID: 37963864
Toll-like receptor 7 (TLR7) is known for eliciting immunity against single-stranded RNA viruses, and is increased in both human and cigarette smoke (CS)-induced, experimental chronic obstructive pulmonary disease (COPD). Here...
3.
Eslick G, Fan K, Nair P, Burns G, Hoedt E, Keely S, et al.
Am J Clin Pathol . 2023 Jun; 160(4):335-340. PMID: 37289435
Objectives: This study aims to determine what pathologic and clinical factors differentiate Brachyspira species that may be useful to clinicians and pathologists. Methods: We identified 21 studies of Brachyspira infection...
4.
Burns G, Bruce J, Minahan K, Mathe A, Fairlie T, Cameron R, et al.
Front Immunol . 2023 Jan; 13:1051632. PMID: 36685573
Background: Functional dyspepsia is characterised by chronic symptoms of post-prandial distress or epigastric pain not associated with defined structural pathology. Increased peripheral gut-homing T cells have been previously identified in...
5.
Fan K, Eslick G, Nair P, Burns G, Walker M, Hoedt E, et al.
J Gastroenterol Hepatol . 2022 Apr; 37(7):1222-1234. PMID: 35385602
Human colonic spirochetosis (CS) is usually due toBrachyspira pilosicolior Brachyspira aalborgiinfection. While traditionally considered to be commensal bacteria, there are scattered case reports and case series of gastrointestinal (GI) symptoms...
6.
Bruce J, Burns G, Soh W, Nair P, Sherwin S, Fan K, et al.
Brain Behav Immun . 2022 Jan; 101:335-345. PMID: 35093492
Functional dyspepsia (FD) affects up to 15% of the population and is characterised by recurring upper gastrointestinal (GI) symptoms occurring in the absence of clinically identifiable pathology. Psychological stress is...
7.
Hu M, Golovchenko N, Burns G, Nair P, Kelly 4th T, Agos J, et al.
Gastroenterology . 2021 Dec; 162(3):877-889.e7. PMID: 34861219
Background & Aims: Excessive shedding of apoptotic enterocytes into the intestinal lumen is observed in inflammatory bowel disease and is correlated with disease relapse. Based on their cytolytic capacity and...
8.
Lu Z, Van Eeckhoutte H, Liu G, Nair P, Jones B, Gillis C, et al.
Am J Respir Crit Care Med . 2021 Jun; 204(6):667-681. PMID: 34133911
Necroptosis, mediated by RIPK3 (receptor-interacting protein kinase 3) and MLKL (mixed lineage kinase domain-like), is a form of regulated necrosis that can drive tissue inflammation and destruction; however, its contribution...
9.
Schanin J, Gebremeskel S, Korver W, Falahati R, Butuci M, Haw T, et al.
Mucosal Immunol . 2020 Aug; 14(2):366-376. PMID: 32814824
In addition to their well characterized role in mediating IgE-dependent allergic diseases, aberrant accumulation and activation of mast cells (MCs) is associated with many non-allergic inflammatory diseases, whereby their activation...
10.
Liu G, Baird A, Parsons M, Fan K, Skerrett-Byrne D, Nair P, et al.
FASEB J . 2020 Apr; 34(6):7718-7732. PMID: 32293760
Liver inflammation is a common extraintestinal manifestation in inflammatory bowel disease (IBD), yet, the mechanisms driving gut-liver axis inflammation remain poorly understood. IBD leads to a breakdown in the integrity...