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Pratibha Bhalla

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Citations 66
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Shi Z, Xiong S, Hu R, Wang Z, Park J, Qian Y, et al.
Dev Cell . 2024 Apr; 59(10):1233-1251.e5. PMID: 38569546
De novo brown adipogenesis holds potential in combating the epidemics of obesity and diabetes. However, the identity of brown adipocyte progenitor cells (APCs) and their regulation have not been extensively...
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Moses A, Bhalla P, Thompson A, Lai L, Coskun F, Seroogy C, et al.
J Allergy Clin Immunol . 2023 Jul; 152(5):1273-1291.e15. PMID: 37419334
Background: Thymus hypoplasia due to stromal cell problems has been linked to mutations in several transcription factors, including Forkhead box N1 (FOXN1). FOXN1 supports T-cell development by regulating the formation...
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Bhalla P, Du Q, Kumar A, Xing C, Moses A, Dozmorov I, et al.
J Clin Invest . 2023 Jul; 133(13). PMID: 37395280
No abstract available.
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Shi Z, Xiong S, Hu R, Wang Z, Park J, Qian Y, et al.
bioRxiv . 2023 Jun; PMID: 37293108
Highlights: PDGFRβ+ pericytes act as an essential developmental brown APC.TBX18+ pericytes contribute to brown adipogenesis in a depot-specific manner.Inhibiting Notch-Pdgfrβ axis promotes brown APC adipogenesis.Enhanced postnatal brown adipogenesis improves metabolic...
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Bhalla P, Du Q, Kumar A, Xing C, Moses A, Dozmorov I, et al.
J Clin Invest . 2022 Sep; 132(22). PMID: 36136514
22q11.2 deletion syndrome (22q11.2DS) is the most common human chromosomal microdeletion, causing developmentally linked congenital malformations, thymic hypoplasia, hypoparathyroidism, and/or cardiac defects. Thymic hypoplasia leads to T cell lymphopenia, which...
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Bhalla P, Su D, van Oers N
Front Immunol . 2022 Jun; 13:864777. PMID: 35757725
The thymus, a primary lymphoid organ, produces the T cells of the immune system. Originating from the 3 pharyngeal pouch during embryogenesis, this organ functions throughout life. Yet, thymopoiesis can...
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Lieu E, Kelekar N, Bhalla P, Kim J
Metabolites . 2021 Aug; 11(8). PMID: 34436420
History suggests that tasteful properties of sugar have been domesticated as far back as 8000 BCE. With origins in New Guinea, the cultivation of sugar quickly spread over centuries of...
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Shukla A, Bhalla P, Potdar P, Jampala P, Bhargava P
RNA . 2020 Dec; PMID: 33277439
The FACT (FAcilitates Chromatin Transactions) complex influences transcription initiation and enables passage of RNA polymerase (pol) II through gene body nucleosomes during elongation. In the budding yeast, ~280 non-coding RNA...
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Bhalla P, Wysocki C, van Oers N
Front Immunol . 2020 May; 11:830. PMID: 32431714
22q11.2 deletion syndrome (DiGeorge), CHARGE syndrome, Nude/SCID and otofaciocervical syndrome type 2 (OTFCS2) are distinct clinical conditions in humans that can result in hypoplasia and occasionally, aplasia of the thymus....