The Notch-Pdgfrβ Axis Suppresses Brown Adipocyte Progenitor Differentiation in Early Postnatal Mice
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Abstract
Highlights: PDGFRβ+ pericytes act as an essential developmental brown APC.TBX18+ pericytes contribute to brown adipogenesis in a depot-specific manner.Inhibiting Notch-Pdgfrβ axis promotes brown APC adipogenesis.Enhanced postnatal brown adipogenesis improves metabolic health in adult stage.
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