Prashant Trikha
Overview
Explore the profile of Prashant Trikha including associated specialties, affiliations and a list of published articles.
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28
Citations
1399
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Recent Articles
1.
Sun S, Angell C, Savardekar H, Sundi D, Abood D, Benner B, et al.
Cancer Immunol Immunother
. 2023 Aug;
72(11):3461-3474.
PMID: 37528320
Myeloid-derived suppressor cells (MDSC) have been linked to loss of immune effector cell function through a variety of mechanisms such as the generation of reactive oxygen and nitrogen species and...
2.
Trikha P, Moseman J, Thakkar A, Campbell A, Elmas E, Foltz J, et al.
Blood Adv
. 2021 Sep;
5(22):4605-4618.
PMID: 34559190
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that regulates cellular processes in cancer and immunity, including innate immune cell development and effector function. However, the transcriptional repertoire...
3.
Ciurea S, Kongtim P, Soebbing D, Trikha P, Behbehani G, Rondon G, et al.
Leukemia
. 2021 Jul;
36(1):155-164.
PMID: 34312462
In this phase I/II clinical trial, we investigated the safety and efficacy of high doses of mb-IL21 ex vivo expanded donor-derived NK cells to decrease relapse in 25 patients with...
4.
Khatua S, Cooper L, Sandberg D, Ketonen L, Johnson J, Rytting M, et al.
Neuro Oncol
. 2020 Mar;
22(8):1214-1225.
PMID: 32152626
Background: Recurrent pediatric medulloblastoma and ependymoma have a grim prognosis. We report a first-in-human, phase I study of intraventricular infusions of ex vivo expanded autologous natural killer (NK) cells in...
5.
6.
Trikha P, Lee D
Biochim Biophys Acta Rev Cancer
. 2019 Dec;
1873(1):188335.
PMID: 31816350
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor (TF) that is a member of the Per-Arnt-Sim family of proteins. AhR regulates diverse processes, including malignant transformation, hematopoietic cell...
7.
Schafer J, Salzillo T, Chakravarti N, Kararoudi M, Trikha P, Foltz J, et al.
J Allergy Clin Immunol
. 2018 Aug;
143(1):346-358.e6.
PMID: 30096390
Background: The mechanism by which natural killer (NK) cell education results in licensed NK cells with heightened effector function against missing self-targets is not known. Objective: We sought to identify...
8.
Kararoudi M, Dolatshad H, Trikha P, Hussain S, Elmas E, Foltz J, et al.
J Vis Exp
. 2018 Jul;
(136).
PMID: 29985369
CRISPR/Cas9 technology is accelerating genome engineering in many cell types, but so far, gene delivery and stable gene modification have been challenging in primary NK cells. For example, transgene delivery...
9.
Stiff A, Trikha P, Mundy-Bosse B, McMichael E, Mace T, Benner B, et al.
Clin Cancer Res
. 2018 Jan;
24(8):1891-1904.
PMID: 29363526
mAbs are used to treat solid and hematologic malignancies and work in part through Fc receptors (FcRs) on natural killer cells (NK). However, FcR-mediated functions of NK cells from patients...
10.
Campbell A, Duggan M, Suarez-Kelly L, Bhave N, Opheim K, McMichael E, et al.
Cancer Immunol Res
. 2017 Jul;
5(9):778-789.
PMID: 28724544
Natural killer (NK) cells are large granular lymphocytes that promote the antitumor response via communication with other cell types in the tumor microenvironment. Previously, we have shown that NK cells...